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Completed

NCT Number: NCT07093424

Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score

Complex Regional Pain Syndrome (CRPS) is a condition triggered by trauma such as surgery or a fracture. It is characterised by pain and limited mobility that are disproportionate to the severity of the trauma and the clinical course. Magnesium is recognised for its anti-inflammatory and antioxidant properties. The magnesium depletion score (MDS) is a more reliable and comprehensive scoring tool than measuring serum and urine magnesium levels. This score takes into account the patient's use of diuretics and proton pump inhibitors, their alcohol consumption, and their glomerular filtration rate. Impaired magnesium distribution may be a risk factor for CRPS development due to increased nociceptor activity. This study aimed to investigate whether an increased MDS score is a risk factor for CRPS development in individuals with traumatic limb injury.

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Key information

Conditions

Complex Regional Pain Syndrome (CRPS) Autonomic Nervous System Diseases Complex Regional Pain Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi

Şişli, Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients aged 18-99 years with traumatic extremity injuries

Exclusion criteria

  • History of previous stroke, spinal cord injury
  • Presence of radiculopathy, radicular pain in the affected extremity
  • Previous surgery for cervical discopathy/lumbar discopathy
  • Presence of oncological, haematological diseases
  • History of previous peripheral nerve injury or previous surgery

Treatment and study plan

scoring

Other

magnesium depletion score calculation

Primary outcomes

  1. CRPS development

    Time frame: baseline

    crps development will be assessed according to Budapest criteria

Sponsors and collaborators

Lead sponsor

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Other

Registry information

Official study title

The Relationship of Magnesium Depletion Score With the Development of Complex Regional Pain Syndrome in Patients With Traumatic Extremity Injury

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 30, 2025
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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