Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kurume University Hospital

Kurume, Fukuoka, 830-0011, Japan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion criteria

Cerebrovascular events within the last 12 months
Acute coronary syndrome, coronary and peripheral intervention within the last 6 months
Uncontrolled heart failure
Other severe systemic diseases

Treatment and study plan

Primary outcomes

The number of circulating EMPs

Time frame: at the time of carotid ultrasound examination

Secondary outcomes

The occurrence of cerebrovascular and/or cardiovascular events

Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Kurume University

Other

Registry information

Important dates

Study start: 2008
Primary completion: 2010
Study completion: 2013
First posted: Nov 21, 2008
Registry last updated: Mar 31, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed