Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.

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Key information

Conditions

Calcium Nephrolithiasis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept. Nephrology & Hypertension, Univ. Hospital Bern

Bern, 3010, Switzerland

About this study

There is epidemiological evidence associating renal calcium stones and decreased bone mineral density (BMD). The decreased BMD in calcium stone formers is linked to hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH levels are encountered under free-choice diet conditions in patients diagnosed with absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports studying the BMD of stone formers and its link with mineral metabolism variables and urinary calcium excretion under different calcium intakes are rare.

We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers with high, intermediate and low BMD are challenged by a low calcium diet.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

passage of at least one calcium containing kidney stone

Exclusion criteria

established cause of calcium stone formation (sarcoidosis, primary hyperparathyroidism etc.)
creatinine clearance < 60 ml/min
urinary tract infection

Sponsors and collaborators

Lead sponsor

Insel Gruppe AG, University Hospital Bern

Other

Registry information

Official study title

Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Important dates

Study start: 2004
Study completion: 2006
First posted: Dec 27, 2006
Registry last updated: May 19, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.