Skip to main content
OpenTrials
Completed

NCT Number: NCT02555670

Relation Between Bioelectrical Impedance Analysis (BIA) and CT-scan Analysis in the ICU

Aim of the present study is to determine whether muscle mass as assessed by bioelectrical impedance analysis correlates with and corresponds to muscle mass as assessed by CT scan analysis in critically patients admitted to the intensive care unit.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Muscular Atrophy Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

BIA measurements are performed in critically ill patients admitted to the ICU or MC, within 72 hours before or after CT scanning.

The BIA measurements are taken with the BIA 101 ASE, manufactured by Akern, Florence-7 Italy. This device is phase sensitive and injects an alternating current of 400 µA at 50 kHz. Measurements were performed while patients lay in supine position with a pillow supporting the head. The resistance, reactance, body weight and length are entered in the BIA algorithm, using BodyGram PRO. This algorithm calculated the body composition, with muscle mass being reported in kilogram (kg).

Abdominal CT scans are analyzed using the computer program SliceOmatic® version 4.3 and 5.0 (TomoVision, Montreal, QC, Canada) at the level of the third lumbar vertebra (L3). The muscle tissue was identified by using boundaries in Hounsfield Units (grayscale) set of -29 to +150(23). The program computes muscle surface area in cm2, by multiplying the pixel area by the amount of pixels identified as muscle.

For a direct comparison with the BIA-derived muscle mass, the CT-derived muscle area is converted to kg. This is done by following two steps. Firstly, the Shen equation is used for the conversion to litres.Secondly, the muscle volume is multiplied by its density, resulting in muscle mass expressed in kg.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Abdominal CT-scan made for diagnostic reasons

Exclusion criteria

  • CT-scan not analysable
  • Internal or external metal devices
  • active pacemaker

Treatment and study plan

BIA

Other

Bioelectrical impedance analysis was performed within 4 days after a CT-scan was made

Other names: Bioelectrical impedance analysis

Primary outcomes

  1. Agreement between BIA-derived muscle mass and CT-derived muscle mass

    Time frame: Patient's data from the ICU-stay will be used, an average of one week

    Agreement will be calculated using a Bland-Altman plot

Secondary outcomes

  1. Sensitivity of BIA to identify low muscle patients

    Time frame: Patient's data from the ICU-stay will be used, an average of one week

    Using CT-derived cut-off points, sensitivity of BIA to identify the same patients as having low muscle will be calculated

  2. Specificity of BIA to identify low muscle patients

    Time frame: Patient's data from the ICU-stay will be used, an average of one week

    Using CT-derived cut-off points, specificity of BIA to identify the same patients as having low muscle will be calculated

  3. Correlation between BIA-derived muscle mass and CT-derived muscle mass

    Time frame: Patient's data from the ICU-stay will be used, an average of one week

    Correlation will be calculated using Pearson's r

Sponsors and collaborators

Lead sponsor

Amsterdam UMC, location VUmc

Other

Registry information

Official study title

Relation Between Bioelectrical Impedance-derived Muscle Mass and CT-derived Muscle Area in Critically Ill Patients

Acronym: ICUBIACT

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Sep 21, 2015
Registry last updated
May 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.