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NCT Number: NCT04810624

Relapse Prevention and Changing Habits in Anorexia Nervosa

This study aims to optimize a treatment package for the relapse prevention treatment of AN. In the Preparation Phase, we examined accessibility and feasibility of the treatment package.

In the current Optimization Phase, we will identify which components of treatment contribute to positive outcomes after acute hospitalization. We will carefully evaluate maintenance of remission, measured by rate of weight loss and end-of-trial status.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

New York State Psychiatric Institute

New York, 10032, United States

Location status: Recruiting

Location contact

Joanna Steinglass, MD

CONTACT

[email protected]

6467746345

Joanna Steinglass, MD

PRINCIPAL_INVESTIGATOR

About this study

While many approaches to reducing relapse after hospital care have been tried, there is little information about which treatment elements confer benefit. This trial, Relapse Prevention and Changing Habits (REACH+), targets the habitual control of maladaptive behavior to support patients with AN in the 6 months after acute treatment, a time of high vulnerability to relapse. Each component of REACH+ addresses a question that is critical to answer in order to identify and optimize a relapse prevention treatment package that balances efficacy and burden. We will test the acceptability and feasibility of 5 components that together target habits: 1) Behavioral, 2) Cognitive, 3)Motivation, 4) Food Monitoring, and 5) Skill Consolidation. In the Preparation Phase, 10 participants were enrolled, and accessibility and feasibility of the treatment package was examined. The current Optimization Phase includes a finalized treatment manual (including an online platform) and will test each component's contribution to weight maintenance after acute treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of Anorexia Nervosa at hospital admission
  • Medically Stable
  • Internet capability with videoconferencing
  • Weight restored (BMI > 19 kg/m2) at New York State Psychiatric Institute

Exclusion criteria

  • Current substance use or other comorbid disorder requiring specialized treatment
  • Pregnancy
  • Imminent risk of suicide
  • Serious medical illness
  • Daily psychotropic medication other than antidepressants (medications that are known effect weight are exclusionary, i.e. stimulants, olanzapine, mirtazapine)
  • Participation in outside psychotherapy or structured treatment program (support groups will be allowed). Individuals who are discharged on medications would need to have a non-study psychiatrist.

Treatment and study plan

Relapse Prevention and Changing Habits (REACH+)

Behavioral

Psychotherapy

Primary outcomes

  1. Weight maintenance

    Time frame: 6-month end of treatment

    Measured via rate of weight loss (in lbs) following discharge from inpatient unit

Secondary outcomes

  1. Habit strength

    Time frame: 6-month end of treatment

    Measured via Self-Report Habit Index (SRHI)

  2. Weight/shape distortion

    Time frame: 6-month end of treatment

    Measured via Eating Disorder Examination, Questionnaire Version (EDE-Q)

  3. Intrinsic motivation

    Time frame: 6-month end of treatment

    Measured via General Self-Efficacy Scale (GSES)

  4. Dietary restriction

    Time frame: 6-month end of treatment

    Measured via Food Choice Task

  5. Skill consolidation

    Time frame: 6-month end of treatment

    Measured via platform utilization time

Study contacts

Contact information is provided by the study sponsor or research team.

Joanna Steinglass, MD

CONTACT

[email protected]

646-774-6345

Sponsors and collaborators

Lead sponsor

New York State Psychiatric Institute

Other

Collaborators

  • Brown University
  • Columbia University
  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Optimizing Relapse Prevention and Changing Habits in Anorexia Nervosa

Acronym: REACH+

Important dates

Study start
2021
Primary completion
2027
Study completion
2027
First posted
Mar 23, 2021
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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