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Completed

NCT Number: NCT06414291

Rehydration Efficiency During Ad-libitum Fluid Intake

It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.

The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.

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Key information

Conditions

Dehydration Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Water-Electrolyte Imbalance

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Interdisciplinary Science and Technology Building 8

Phoenix, Arizona, 85004, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-60 years
  • Training at least 2 times per week
  • stable weight for the last 2 months (fluctuation less than 5 pounds)

Exclusion criteria

  • Night shifting work
  • Thyroid medication
  • Bariatric surgery
  • Cardiovascular disease
  • Renal disease
  • Hepatic disease
  • Participating in another study at the same time
  • Bodyweight over 110 pounds

Treatment and study plan

Plain Water

Other

Plain water without calories, sweetener, or electolytes

Liquid IV Hydration Multiplier

Other

Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV

Liquid IV Sugar Free

Other

10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV

Primary outcomes

  1. Total fluid intake

    Time frame: 4 hours of rehydration

    Total amount of fluid ingested

  2. Net fluid balance

    Time frame: at 4 hours of the rehydration period

    amount of water retained during the rehydration period

  3. Net fluid balance

    Time frame: at 3 hours of the rehydration period

    amount of water retained during the rehydration period

  4. Rate of absorption

    Time frame: during the first 30 minutes of rehydration

    The rate of Deuterium appearance in the blood during 30 minutes of rehydration

  5. Rate of absorption

    Time frame: during the first 60 minutes of rehydration

    The rate of Deuterium appearance in the blood during 60 minutes of rehydration

  6. Rate of absorption

    Time frame: during the first 120 minutes of rehydration

    The rate of Deuterium appearance in the blood during 120 minutes of rehydration

  7. Rate of absorption

    Time frame: during the first 180 minutes of rehydration

    The rate of Deuterium appearance in the blood during 180 minutes of rehydration

  8. Rate of absorption

    Time frame: during the first 240 minutes of rehydration

    The rate of Deuterium appearance in the blood during 240 minutes of rehydration

  9. Cumulative urine output

    Time frame: during the first 3 hours of rehydration

    Total amount of urine output during rehydration

  10. Cumulative urine output

    Time frame: during the first 4 hours of rehydration

    Total amount of urine output during rehydration

Secondary outcomes

  1. Plasma copeptin

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Plasam Copeptin during rehydration

  2. Plasma volume

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    percent of plasma volume recovery during the rehydration

  3. Free water Clearance

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Free water clearance calculated based on plasma and urine osmolality

  4. Free Osmotic Clearance

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Free Osmotic clearance calculated based on plasma and urine osmolality

  5. Thirst

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception

  6. Stomach fullness

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception

  7. Taste Likeness

    Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period

    Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception

Sponsors and collaborators

Lead sponsor

Arizona State University

Other

Registry information

Acronym: LIV-D2O

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 16, 2024
Registry last updated
Aug 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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