Rehabilitation in Parkinson Disease Cyclone in Life

rehabilitation protocols in patients with Parkinson's disease and, therefore, identification of innovative rehabilitation protocols of proven and validated efficacy, through which it is possible to achieve:

Improved joint function and gait pattern Reduction of the risk of falling or reduction of energy expenditure during physiological gait Evaluation of the increase in maximal effort tolerance

· Improved cognitive performances

Evaluation of the impact on the quality of life of the patient and family members

Identification of morpho-functional markers predictive of clinical and rehabilitative out-come through neuroimaging study.

Inclusion criteria

• Hoehn & Yahr between 2.0 and 3.0;
• No need for a walking aid;
• Mini-Mental State Examination (MMSE) score >24;
• Effective dopaminergic pharmacological control;
• Absence of other relevant neurological comorbidities;
• Absence of postural deformities (and/or Pisa syndrome);
• Absence of severe cardiological pathologies (exertional angina, severe decompensation).
• Ability to travel to the rehabilitation treatment site independently or with support

Exclusion criteria

• presence of Deep Brain Stimulation (DBS);
• presence of severe heart and/or lung disease;
• presence of therapeutic regimen in the definition phase;
• impaired joint and/or motor function to follow a proposed rehabilitation treatment programme
• contraindications to performing MRI scans
• undergoing rehabilitation therapy in the 3 months preceding enrolment.