Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

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Key information

Conditions

Osteoarthritis Arthritis Behavior Exercise Inflammation Joint Diseases Motor Activity Musculoskeletal Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Rheumatic Diseases

Age range

55 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

verified osteoarthritis (x-ray)of the knee, female,

Exclusion criteria

dementia, inflammatory diseases, regular pain medication

Treatment and study plan

Exercise

Other

Non Exercise

Other

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Collaborators

Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
The Danish Rheumatism Association

Registry information

Important dates

Study start: 2008
Primary completion: 2009
First posted: Mar 19, 2010
Registry last updated: Mar 19, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed