Regulation of Inflammatory Genes in Psoriasis

Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as markers in the severity and management of the disease after further in-depth studies.

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Key information

Conditions

Psoriasis Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

19 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Kirklin Clinic

Birmingham, Alabama, 35294, United States

Location status: Recruiting

Location contact

Wendy Cantrell

CONTACT

[email protected]

205 502 9960

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of psoriasis
Must be age 19 or older.
Must be Fitzpatrick skin type I, II, III, IV, V, VI.

Exclusion criteria

Subjects who do not have photosensitive disease and are not on photosensitizing medications.
Subjects with a history of keloids (who are more likely to develop hypertrophic scars following skin biopsy).
Subjects who have an allergy to local anesthetics, antibiotics and/or anticoagulants.
Subjects who are pregnant.

Treatment and study plan

inflammatory markers

Diagnostic Test

Primary outcomes

Inflammatory genes

Time frame: 1 day

TNF-alpha , IFN-alpha , IL-6, IL-8, IL-12 , IL-23, IL-4, IL-5 and IL-10

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2027
Study completion: 2028
First posted: Apr 24, 2017
Registry last updated: Apr 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed