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Completed

NCT Number: NCT06556875

Regulation of HIIT Combined with IET on Vascular Function in Young Women with Normal Weight Obesity

Comparison of the effects of combined IET with HIIT and HIIT on vascular function in young NWO women.

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Key information

Conditions

Normal Weight Obesity

Age range

18 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, China

About this study

This is a randomized clinical trial of single-blind with 3 arms (control group , HIIT group and IET with HIIT group), in which a pre-treatment-posttest design has been used.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female, aged between 18 and 30 years old;
  • BMI between 18.5 and 24.9 kg/m2 with a BF% > 30% (normal weight obesity determination criteria);
  • exercise capacity to complete the exercise programme.

Exclusion criteria

  • Acute or chronic musculoskeletal disorders, cardiovascular diseases, etc. that prevented training;
  • other diseases (such as diabetes, etc.) that had a great impact on physical condition;
  • bad habits (such as smoking, drinking, etc.);
  • and unstable body weight (up and down fluctuations of more than 2.5 kg) in the 3 months before the experiment.

Treatment and study plan

HIIT

Behavioral

high intensity interval training

HIIT combined IET

Behavioral

high intensity interval training combined with isometric exercise training

Primary outcomes

  1. Intima-Media Thickness (IMT)

    Time frame: 8 weeks

    The subjects were required to sit still for 5～10 minutes before the test, and the carotid artery structural and functional parameters were recorded using a GE vivid 7 colour ultrasound instrument from the United States as follows: the subjects were required to lie in the supine position, and the probe was used to sweep longitudinally along the outer edge of the sternocleidomastoid muscle, and the maximal Intima-media thickness (IMT) was measured. Changes in Intima media thickness before and after intervention.

  2. Flow-Mediated Dilation (FMD)

    Time frame: 8 weeks

    Vascular endothelial function was measured with a Japanese-made UNEX EF vascular endothelial function tester. Pressure was applied on top of the resting blood pressure and the ischaemic process was performed for 5 min. At the end of the ischaemic process, the pressure band was removed and flow-mediated dilation (FMD) of the brachial artery was calculated. Changes in Flow-mediated dilation before and after Intervention

Secondary outcomes

  1. Body Composition Indicators

    Time frame: 8 weeks

    Body composition indicators analysis was assessed using DXA. Body composition indicators include: fat mass(kg), lean body mass(kg), percentage of body fat(%).

  2. Body Mass Index (BMI)

    Time frame: 8 weeks

    Is calculated from the formula, Weight (kg) / Height2 (m2), whose unit is kg/m2. It is a rough indicator of total body fat. Changes in Body mass index before and after Intervention.

  3. Blood Pressure (BP)

    Time frame: 8 weeks

    Quiet blood pressure: Systolic and diastolic blood pressures are measured using a standard mercury sphygmomanometer. Changes in blood pressure before and after intervention, including systolic blood pressure, diastolic blood pressure, and pulse pressure difference.

  4. Pulse Wave Velocity (PWV) and ankle brachial index (ABI)

    Time frame: 8 weeks

    The testing instrument is Omron Atherosclerosis Tester (BP-203RPEIII). During the test, the subjects need to expose their limbs, lie flat on the bed, and keep their bodies relaxed. At the same time, they need to tie cuffs around their limbs to avoid any physical movement and ensure the accuracy of the test results. The unit of PWV is (cm/s), and ABI is a numerical value. Changes in Pulse wave velocity and ankle brachial index before and after Intervention.

  5. Volume Oxygen Maximum (VO2max)

    Time frame: 8 weeks

    During the test, gradually increasing loads were performed using the Bruce running table protocol, and gas metabolism metrics were obtained at each stage of exercise using a portable Cortex-3B gas metabolism analyser. Changes in Volume oxygen maximum before and after Intervention.

Sponsors and collaborators

Lead sponsor

Beijing Sport University

Other

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Aug 16, 2024
Registry last updated
Oct 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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