REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

Key Inclusion Criteria:

• Is undergoing a primary elective unilateral TKA
• Is in good health based on laboratory safety testing as described in the protocol
• Body weight ≤130 kg at screening visit as described in the protocol

Key Exclusion Criteria:

• Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study participation
• History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion as described in the protocol
• History of thromboembolic disease or thrombophilia
• History of major surgery, including brain, spinal, or ocular, or major trauma within approximately the past 6 months prior to randomization
• Has an estimated Glomerular Filtration Rate (GFR) of <30 mL/min/1.73 m2 at the screening visit as described in the protocol

Note: Other protocol-defined Inclusion/ Exclusion Criteria apply