Shanghai Ruijin Hospital
Shanghai, Shanghai Municipality, 200025, China
Location status: Recruiting
NCT Number: NCT06534463
This study aims to evaluate real-world treatment modalities and their corresponding effectiveness and safety in Chinese patients with marginal zone lymphoma, while also exploratively analyzing patient characteristics and health-related quality of life.
Interested in participating?
Request Info14 year and older
All sexes
Observational
Shanghai, Shanghai Municipality, 200025, China
Location status: Recruiting
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
The dosage and duration of any drug in this study will be determined by the physician based on local clinical practice and local drug labels. The drugs in this study include, but are not limited to, Obinutuzumab, Rituximab, Bruton tyrosine kinase inhibitors, and Lenalidomide. In this non-interventional study, all treatment drug usage will be determined by the physician based on clinical practice and/or the respective drug labels in China.
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Progression-free survival was defined as the time from the date of diagnosis until the date of the first documented day of disease progression or relapse, using 2014 Lugano criteria, or death from any cause, whichever occurred first.
Time frame: End of treatment visit (approximately 6 months)
Percentage of participants with overall response was determined on the basis of investigator assessments according to 2014 Lugano criteria.
Time frame: End of treatment visit (approximately 6 months)
Percentage of participants with complete response was determined on the basis of investigator assessments according to 2014 Lugano criteria.
Time frame: From the start of treatment to the initiation of next-line treatment (up to approximately 60 months)
From the start of treatment to the initiation of next-line treatment
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Time from first occurrence of documented complete response or partial response to disease progression/relapse, or death from any cause for participants, whichever occurs first.
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Time from the first occurrence of a documented complete response to the date of progression, relapse, or death from any cause, whichever occurs first.
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Overall survival was defined as the time from the date of diagnosis to the date of death from any cause.
Time frame: Baseline up to data cut-off (up to approximately 60 months)
An adverse event is any untoward medical occurrence in a participant administered a pharmaceutical product and which does not necessarily have to have a causal relationship with the treatment. An adverse event can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding, for example), symptom, or disease temporally associated with the use of a pharmaceutical product, whether or not considered related to the pharmaceutical product. Preexisting conditions which worsen during a study are also considered as adverse events.
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Patient-reported outcomes using The European Organization for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) .
Time frame: Baseline up to data cut-off (up to approximately 60 months)
Patient-reported outcomes using The European Organization for Research and Treatment of Cancer Quality of Life questionnaire including 20 items for patients with low-grade non-Hodgkin lymphoma (EORTC QLQ-NHL-LG20).
Contact information is provided by the study sponsor or research team.
Ruijin Hospital
Other
The Effectiveness and Safety of Different Treatment Modalities in Real-World Clinical Practice Among Chinese Patients with Marginal Zone Lymphoma: a Prospective, Observational, Multi-center Study
Acronym: MOTIVE
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT05006716
B-cell Malignancy, Blood Protein Disorders
Birmingham, Alabama, United States
View Trial DetailsNCT05805605
Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia
Minneapolis, Minnesota, United States
View Trial DetailsNCT06860880
Behavior, Blood Protein Disorders
Chapel Hill, North Carolina, United States
View Trial DetailsNCT06636175
Blood Protein Disorders, Cardiovascular Diseases
St Louis, Missouri, United States
View Trial Details