Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population

The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.

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Key information

Conditions

Right-To-Left Shunt Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebral Infarction Cerebrovascular Disorders Headache Disorders Headache Disorders, Primary Infarction Ischemia Migraine Migraine Disorders Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Vascular Diseases

Age range

16 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

First Hospital of Jilin University

Changchun, Jilin, 130000, China

About this study

This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.

The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For group 1: Normal healthy individual without migraine.
For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.

Exclusion criteria

Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.

Treatment and study plan

Primary outcomes

contrast-enhanced transcranial Doppler

Time frame: 1 year

Secondary outcomes

brain MRI

Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Yingqi Xing

Other

Registry information

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2017
First posted: Apr 24, 2015
Registry last updated: Jan 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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