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Recruiting

NCT Number: NCT03410394

Registry of Endocrine Tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube)

This registry aims to collect informations about patients with endocrine tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube) who undergo endocrine surgical procedures. This registry is part of the Eurocrine Project.

Recruiting

Interested in participating?

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Nancy

Vandœuvre-lès-Nancy, 54511, France

Location status: Recruiting

Location contact

laurent Brunaud

CONTACT

[email protected]

About this study

The EUROCRINE project aims to decrease morbidity and mortality of rare endocrine tumours, by means of a pan-European database. Recording and accessing data at the European level, makes it possible to identify these tumours, which cannot be distinguished at local or national level, because of their extreme rarity. Dissemination of results aims to raise clinical standards and reduce differences in practise between clinics and member states, and thereby diminish morbidity and mortality. Comparison of practice and outcomes will be especially interesting for centres wanting to improve their standards to what is currently considered best practice. EUROCRINE will be a key means by which the medical profession, researchers, health policy makers, and not least patients, can benefit from an increase in knowledge related to diagnosis, treatment, and future clinical research in the field of rare endocrine tumours.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who undergo surgical procedures for endocrine tumors at the University Nancy Brabois Hospital

Exclusion criteria

  • unable to receive clear information
  • refusal to sign the consent form

Treatment and study plan

Primary outcomes

  1. Postoperative complications (endocrine surgical procedure)

    Time frame: 12 months after surgical procedure

    morbidity rate in percentage (%)

Secondary outcomes

  1. Postoperative complications severity (endocrine surgical procedure)

    Time frame: 12 months after surgical procedure

    Dindo-Clavien classification in percentage (%)

  2. Postoperative mortality (endocrine surgical procedure)

    Time frame: 12 months after surgical procedure

    mortality rate in percentage (%)

  3. CT imaging before endocrine surgical procedure (Tumor characteristics)

    Time frame: Baseline

    Density in Hounsfield unit (HU)

  4. CT imaging before endocrine surgical procedure (Coronary artery score)

    Time frame: Baseline

    CAC score in Agatston score unit (HU)

  5. CT imaging before endocrine surgical procedure (Sarcopenia)

    Time frame: preoperative period

    Evaluation of sarcopenia using L3 skeletal muscle index (in cm²/m²)

  6. Bone mineral density

    Time frame: Baseline

    dual-energy x-ray absorptiometry (DEXA) (in T-score unit)

  7. Intraoperative systolic arterial pressure

    Time frame: Intraoperative

    systolic arterial pressure (in mmHg)

  8. Intraoperative diastolic arterial pressure

    Time frame: Intraoperative

    diastolic arterial pressure (in mmHg)

  9. Parathormone plasma levels

    Time frame: Baseline and up to 12 months after surgical procedure

    Parathormone (in pg/mL)

  10. Aldosterone plasma levels

    Time frame: Baseline and up to 12 months after surgical procedure

    Aldosterone (in pmol/L)

  11. Plasma renin activity

    Time frame: Baseline and up to 12 months after surgical procedure

    Renin (in μIU/mL)

  12. Plasma free metanephrines

    Time frame: Baseline and up to 12 months after surgical procedure

    metanephrines (in nmol/L)

  13. PET scanning

    Time frame: Baseline

    standardized uptake values (SUV tumor / SUV liver ratio)

Study contacts

Contact information is provided by the study sponsor or research team.

Brunaud

CONTACT

[email protected]

laurent Brunaud, MD, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Registre Tumeurs Endocrine - Eurocrine

Acronym: eurocrine

Important dates

Study start
2015
Primary completion
2030
Study completion
2030
First posted
Jan 25, 2018
Registry last updated
Feb 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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