Reduction of Asthma Exacerbation Rate in Children by Non-invasive Monitoring of Inflammatory Markers in Exhaled Breath (Condensate): the RASTER Study

The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation. In addition, the reliability of home monitor assessments to measure asthma control will be examined.

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Key information

Conditions

Asthma Bronchial Diseases Children Exhaled Breath Condensate Home Monitoring Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Non-invasive Inflammatory Markers Respiratory Hypersensitivity Respiratory Tract Diseases Volatile Organic Compounds

Age range

6 year–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Maastricht University Hospital, Maastricht, Netherlands

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

already known with a diagnosis of asthma during at least 6 months
age between 6 and 17 years
reversibility to a bronchodilator (increase in FEV1 > 9% of predicted value and/or
bronchial hyperresponsiveness to histamine < 8 mg/ml.

Exclusion criteria

cardiac abnormalities
mental retardation, congenital abnormalities or existence of a syndrome
active smoking
no technical satisfactory performance of measurements
no phone line or internet assess available at home.

Treatment and study plan

Primary outcomes

number of exacerbations

Time frame: 1 year

increase of asthma symptoms, use of short b2-agonists, drop in FEV1% of maximum personal value.
asthma control

Time frame: 1 year

asthma control questionnaire
Quality of life

Time frame: 1 year

Asthma Quality of Life questionnaire for children

Secondary outcomes

cost-effectiveness

Time frame: 1 year

incremental cost per exacerbation prevented

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Collaborators

ZonMw: The Netherlands Organisation for Health Research and Development

Registry information

Acronym: RASTER

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2013
First posted: Nov 11, 2010
Registry last updated: Nov 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed