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OpenTrials
Completed

NCT Number: NCT04657185

Reducing Perioperative S. Aureus Transmission Via OR PathTrac

Healthcare-associated infections (HAIs) occur frequently and are associated with patient harm. It is important that healthcare facilities take the necessary steps to prevent the spread of resistant bacteria. ESKAPE bacteria (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) are particularly pathogenic. Isolation of these pathogens from intraoperative reservoirs has been associated with postoperative infection development (i.e. surgical site infections). This project involves implementation of a software platform and bacterial collection system (OR PathTrac) that leverages the epidemiology of intraoperative bacterial transmission to guide dynamic, prospective improvements in perioperative infection control measures. The investigators will assess the effectiveness of OR PathTrac feedback in optimizing an evidence-based, multifaceted, perioperative infection control program.

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Key information

Conditions

S. Aureus Transmission Bacterial Infections Bacterial Infections and Mycoses Gram-Positive Bacterial Infections Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Staphylococcal Infections Surgical Site Infection Surgical Wound Infection Wound Infection

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Georgetown University

Georgetown, District of Columbia, 20057, United States

About this study

Our objective was to analyze the impact of surveillance feedback optimization of a multifaceted, perioperative infection control program on S. aureus transmission and SSIs. A multifaceted infection control program was implemented over 8 months (November 2018 to June 2019). A prospective cohort impact study was then conducted over 8 months (July 2019 to March 2020) to compare the incidence of within-case S. aureus transmission (primary outcome) and surgical site infection (secondary outcome) before (4.5 months) and after (3.5 months) implementation of surveillance feedback.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients requiring anesthesia and intravenous catheter placement.

Exclusion criteria

  • Pediatric patients, without requirement of anesthesia and/or intravenous catheter placement.

Treatment and study plan

OR PathTrac Feedback Optimization

Other

OR PathTrac (RDB Bioinformatics, Omaha, NE 68154) uses a systematic phenotypic approach leveraging temporal association to monitor 13 anesthesia work area reservoirs proven to be associated with high-risk intraoperative bacterial transmission events and subsequent infection development.

Primary outcomes

  1. within-case S. aureus transmission

    Time frame: From patient entry into the operating room until case end, up to 6 hours

    S. aureus transmission events detected within a surgical case

Secondary outcomes

  1. surgical site infection

    Time frame: Up to 90 days following surgery

    evidence of infection (office note documentation with anti-infective order and/or isolation of one or more potentially pathogenic organisms

Sponsors and collaborators

Lead sponsor

Georgetown University

Other

Collaborators

  • RDB Bioinformatics
  • Trustees of Dartmouth College
  • University of Iowa

Registry information

Official study title

Reducing Perioperative S. Aureus Transmission Via Use of an Evidence-Based, Multimodal Program Driven by an Innovative Software Platform (OR PathTrac)

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Dec 8, 2020
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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