Red Yeast Rice for Primary Prevention of Hypercholesterolemia

Inclusion criteria

• Aged 35~55 years old
• LDL-C≥130mg/dl or patients with diabetes or chronic kidney disease with LDL-C ≥ 100mg/dl
• expected to receive LipoCol Forte Capsule 600mg bid

Exclusion criteria

• Have received anti-hyperlipidemic drugs or red yeast rice treatment within the past month;
• Female;
• Have experienced rhabdomyolysis or abnormal liver function ALT >72 U/L due to taking red yeast rice;
• Bleeding diseases, such as abnormal platelets, abnormal coagulation factors, or gastrointestinal tract infection within one month
• Liver insufficiency ALT >72 U/L or renal insufficiency eGFR < 30 mL/min/1.73 m2;
• Have ever had coronary heart disease, myocardial infarction or cerebrovascular disease;
• Stressful situations, including hospitalization or surgery within the past or next month, and cancer still being treated;
• Uncontrolled hypertension (blood pressure ≥160/100 mmHg);
• Use antibiotics, probiotics or weight-loss drugs for more than 3 consecutive days within 3 months before inclusion in the study;
• Drug abuse or poor compliance;
• Use of traditional Chinese medicine in the past month