Recurrent Pterygium Surgery Using Mitomycin C With Limbal Conjunctival or Amniotic Membrane

Excision alone for treating recurrent pterygium was reported to be at risk of high recurrence again. As one of adjunctive methods, intraoperative application of a single dose of mitomycin C (MMC) seems to be the most commonly used method for preventing recurrence of pterygium. Additionally, closure of conjunctival defect after excision of pterygium by limbal conjunctival autograft or amniotic membrane have also become popular in recent years. There are a few reports in which MMC combined either limbal conjunctival autograft (LCAG) or amniotic membrane graft (AMG) for the treatment of recurrent pterygium. To assess the effectiveness and safety of these two combined approaches, the investigator plans to work on a randomized comparative and prospective trial of recurrent pterygium extensive excision with intraoperative 0.02% MMC application comparing LCAG to AMG.The patients enrolled in this study will be followed for at least 12 months after the surgery. Recurrence was defined as fibrovascular tissue crossing the limbus on to the clear cornea in the area of previous pterygium excision.

Inclusion criteria

• The patients had one or two eye(s) with unilateral recurrent pterygium.
• Recurrent pterygium：be defined as of fibrovascular tissue onto the cornea for any distance in the position of a previous pterygium.
• Willingness to participate in research project and to attend research time.

Exclusion criteria

• Poor general health.
• Pregnant or lactating women.
• Patients with collagen vascular diseases or other autoimmune diseases.
• Patients with any evidence of stem cell deficiency.
• Patients with glaucoma who might require future filtering surgery.
• Patients with ocular infection.
• Patients with an allergy to mitomycin C, tobramycin or dexamethasone.