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NCT Number: NCT06583317

Recurrent Pneumonia in Children

This study aimed to analyses the clinical characteristics, risk factors and underlying causes as predictors of recurrent pneumonia in children attending AUCH

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Key information

Age range

30 day–18 year

Sex eligibility

All sexes

Study type

Observational

About this study

Pneumonia is defined as inflammation of lung parenchyma due to various pathogenic organisms including bacteria, viruses, fungi and parasites. The key symptom to suspect childhood pneumonia is tachypnea. The World Health Organization (WHO) has defined tachypnea as respiratory rate >60 breaths/min in infants less than 2 months, >50 in infants 2 -12 months and >40 in children 1 to 5 years and >20 in children >5 years of age [1]. WHO has categorized pneumonia in children under-five years of age into two categories, pneumonia and severe pneumonia. Tachypnea with or without chest retraction is categorized as pneumonia while tachypnea with any danger signs (unable to feed or drink, hypothermia, unconsciousness, convulsion, signs of hypoxia including cyanosis, grunting, groaning, head nodding) as severe pneumonia [1].

Pneumonia is a common and described as the overlooked killer of children[2] as killing 1.1-1.4 million children every year. It accounts for 17%-19% of all deaths amongst children under 5 years of age; the majority of them are in developing countries [3,4] .In Egypt, children under 5 years approximate 13.4% of the total population[4] and pneumonia constitutes 19% of under-five mortality[5].

Recurrent pneumonia (RP) is defined as at least two episodes of pneumonia in one year or three episodes ever, with intercritical radiographic clearing of densities [6]. Incidence data indicate that RP occurs in 7.7%-9% of all children with CAP [7,8,9,10,11,12]. As a result, RP represents a frequent presenting manifestation in the general pediatric practice and is a very common reason for referral to pediatric chest physicians [7]. Factors linked to these infections could be recurrent aspirations, congenital structural anomalies of pulmonary and cardiovascular systems, defects in the clearance of airway secretions and immunodeficiency [13]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • All children more than 1 month and less than 18 years of age
  • All cases presented by picture of recurrent pneumonia in the form of as at least two episodes of pneumonia in one year or three episodes ever, with radiographic clearing of densities in between.

Exclusion criteria

  • • All children less than 1 month and more than 18 years
  • Evidence of malignancies
  • Evidence of congenital immune deficiency
  • Cases refusing to participate in research.
  • Cases missed for follow up.

Treatment and study plan

Primary outcomes

  1. To delineate risk factors of recurrent chest infection.

    Time frame: Baseline

    Characteristics of studied children in AUCH as in feeding, nutritional status and growth parameters.

Study contacts

Contact information is provided by the study sponsor or research team.

Dalia Abdelnaser Marouf, Bachelor of Medicine

CONTACT

[email protected]

01093573433

Maher Mokhtar Ahmed, Professor of Pediatrics

CONTACT

[email protected]

01066006605

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Recurrent Pneumonia in Children at Assiut University Children's Hospital

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Sep 4, 2024
Registry last updated
Sep 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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