Recovery Hypoxemia After Sedated Upper Gastrointestinal Endoscopy

Sedation during upper gastrointestinal endoscopy may lead to respiratory events not only during the procedure but also in the early recovery period. Although most hypoxemic episodes are considered transient, their frequency, duration, and clinical consequences during recovery remain insufficiently defined.

This prospective observational study aims to evaluate the incidence, duration, and clinical impact of recovery-period hypoxemia following sedated upper gastrointestinal endoscopy. Hypoxemia is defined as SpO₂ <90% lasting ≥10 seconds. Associated respiratory events and potential risk factors will be analyzed without altering routine clinical practice.

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Key information

Conditions

Hypoxemia Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged ≥18 years
Scheduled for upper gastrointestinal endoscopy (EGD) under anesthesiologist-administered sedation
Able to undergo post-procedure monitoring in the recovery unit
Provided written informed consent for participation and data use

Exclusion criteria

Colonoscopy or combined procedures (EGD + colonoscopy)
Emergency procedures or procedures performed under intensive care conditions
Requirement for endotracheal intubation, noninvasive ventilation, or advanced airway support during the procedure
Known severe upper airway anatomical abnormalities, facial deformity, or tracheostomy
Inability or refusal to provide informed consent
Incomplete or unavailable recovery-period oxygen saturation monitoring data

Treatment and study plan

Sedated Upper Gastrointestinal Endoscopy

Other

Routine upper gastrointestinal endoscopy performed under anesthesiologist-administered sedation. No experimental intervention is applied; the study prospectively observes respiratory events during the recovery period as part of standard clinical care.

Primary outcomes

Recovery-Period Respiratory Events

Time frame: From end of procedure (scope-out) until discharge from recovery unit

Occurrence of respiratory events during the recovery period following sedated upper gastrointestinal endoscopy, defined as at least one of the following:

SpO₂ <90% lasting ≥10 seconds

Requirement for airway maneuver (jaw-thrust, chin-lift, OPA/NPA, mask ventilation)

Escalation or re-initiation of supplemental oxygen

Study contacts

Contact information is provided by the study sponsor or research team.

ilke dolgun

CONTACT

[email protected]

+905555485632

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

Incidence, Duration, and Clinical Impact of Recovery-Period Hypoxemia Following Sedated Upper Gastrointestinal Endoscopy: A Prospective Observational Study

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Mar 3, 2026
Registry last updated: Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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