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OpenTrials
Completed

NCT Number: NCT04824781

Recovery From Paranoia: a Qualitative Exploration

Paranoia, the experience of undue or excessive mistrust, exists on a continuum which includes suspicious thoughts, ideas of reference, and persecutory delusions. Persecutory delusions refers to strong unfounded fears that others intend harm. These fears are very common. They affect around 70% of patients with schizophrenia. They can be distressing and make day-to-day tasks difficult. However, current treatments are limited and a significant proportion of people do not benefit sufficiently. Therefore, improvements in treatment are needed. A better understanding of the experience of recovery from paranoia will help inform theoretical understanding and treatment development. Currently we do not fully understand what causes paranoia to occur, persist, or end. As such, it is critical to understand the experiences of those who have recovered, in particular what elements encourage recovery. Therefore, the aim of this study is to gain a first-person perspective on how people recover from paranoia and what psychological processes are important for recovery from paranoia. Using a qualitative approach appropriate for exploratory research, semi-structured interviews will be conducted with 12-15 patients who have recovered from paranoia. Interviews will be analysed using interpretative phenomenological analysis, a qualitative research approach which aims to provide insight on how an individual, in a particular situation, makes sense of their experience.

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Key information

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Oxford Health NHS Foundation Trust

Oxford, Oxfordshire, OX3 7JX, United Kingdom

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participant has recovered from the paranoia. This is defined as: A.) conviction in persecution beliefs is rated as less than 10% and B.) not experiencing significant distress related to paranoia and C.) currently scoring outside the clinical range of the revised Green et al., Paranoid Thoughts Scale (R-GPTS; Freeman, 2019);
  • Participants should have had experiences of paranoia in the context of non-affective psychosis. This will be determined by participant's agreement that they previously had the sort of thoughts listed in the revised Green et al. Paranoid Thoughts Scale (R-GPTS; Freeman, 2019);
  • Participant is currently a patient of Oxford Health NHS Foundation Trust;
  • Participant is willing and able to give informed consent for participation in the study;
  • Aged 16 years or above;
  • Participant has sufficient English language skills to participate in the interview.

Exclusion criteria

The following exclusion criteria will apply based on concerns regarding risk and capacity to consent:

  • Currently experiencing acute psychiatric symptoms which preclude ability to participate in a sustained interview;
  • Diagnosis of a moderate to severe intellectual disability;
  • High levels of associated risk to self or to others e.g. actively suicidal;
  • Primary diagnosis of alcohol or drug misuse; personality disorder; significant forensic history;
  • At the time of recruitment COVID-19 restrictions do not permit face-to-face interviews and the participant is not willing or able to conduct the interview remotely via video call.

Treatment and study plan

Qualitative interview

Other

Participants will be interviewed about their experiences of recovery from paranoia.

Primary outcomes

  1. Qualitative interview accounts

    Time frame: March 2021-March 2022

    Semi-structured interpretative phenomenological analysis (IPA) interviews will be used.

Sponsors and collaborators

Lead sponsor

University of Oxford

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Apr 1, 2021
Registry last updated
May 19, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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