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OpenTrials
Completed

NCT Number: NCT04788030

Reconstruction of Digital Nerve Lesions With Muscle-in-Vein Conduits

Muscle-in-vein conduits (MVCs) provide an alternative for bridging digital nerve defects when tension-free suture is not possible. Low donor site morbidity and absence of additional costs are favorable advantages compared to autografts or conduits. 37 patients with 43 defects of proper palmar digital nerves were retrospectively enrolled. Primary repair by MVCs was performed in 22 cases while 21 underwent secondary reconstruction. Recovery of sensibility was assessed by static and moving two-point discrimination (2PDs, 2PDm) and Semmes-Weinstein monofilaments (SWM). Results were compared with contralateral side serving as intraindividual control. Outcome data were stratified according to international guidelines and evaluated for differences in terms of age, gap length, time of reconstruction and concomitant injuries.

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Key information

Conditions

Peripheral Nerve Injury Upper Limb

Age range

6 year–72 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with reconstruction of digital nerves with muscle-in-vein conduits

Exclusion criteria

  • Subtotal or total amputations
  • pre-existing neurological disorders (e.g. polyneuropathy)
  • symptoms of nerve entrapment

Treatment and study plan

Nerve reconstruction

Other

Nerve bridging with muscle-in-vein conduits

Primary outcomes

  1. Two-point discrimination

    Time frame: Six months after reconstruction or later

  2. Semmes-Weinstein-Monofilament test

    Time frame: Six months after reconstruction or later

Secondary outcomes

  1. Age

    Time frame: Baseline

  2. Gap length

    Time frame: Baseline

  3. Time of reconstruction

    Time frame: Baseline

  4. Concomitant injuries

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

BG Trauma Center Tuebingen

Other

Registry information

Official study title

Outcome After Reconstruction of 43 Digital Nerve Lesions With Muscle-in-Vein Conduits

Important dates

Study start
2008
Primary completion
2017
Study completion
2021
First posted
Mar 9, 2021
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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