RECO Flow Restoration Device Versus Solitaire FR With the Intention for Thrombectomy Study

RECO is a novel, self-expanding stent retriever, designed to yield rapid flow restoration in acute cerebral ischaemia. The proposed study is a multicenter, randomized, prospective, parallel-group, open-label clinical trial with a blinded outcome, to test the RECO(a novel, self-expanding stent retriever), as compared with Solitaire FR stent retriever.

Inclusion criteria

• age (18-80 years)
• acute ischemic stroke
• within 8 hours after symptom onset
• a large-vessel confirmed by CTA/MRA (eg, internal carotid, middle cerebral M1 and/or M2 segments)
• NIHSS(≥8 and ≤24)
• patients or their legally authorised representatives provided signed, informed consent.

Exclusion criteria

• CT or MRI evidence of intracranial haemorrhage/tumor
• major ischaemic infarction (acute ischaemic change in more than a third of the middle cerebral artery territory)
• NIHSS(≥25 and ≤7)
• severe sustained hypertension (systolic blood pressure >185 mm Hg or diastolic blood pressure >110 mm Hg)
• baseline glucose concentrations of less than 2·7 mmol/L or higher than 21.6 mmol/L
• known haemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with an international normalised ratio of more than 1.7
• treatment with heparin within 48 h with a partial thromboplastin time more than two times the laboratory normal, baseline platelet count of less than 100×10^9/L
• history of severe allergy (worse than rash) to contrast medium or nitinol
• pregnancy