Completed

NCT Number: NCT01339013

Rebreathing of Carbon Dioxide With a Device Used for Giving Inhalational Anaesthesia

The anesthesia gas reflector (AnaConDa) is built on the adsorptive capacity of active carbon which also adsorbs carbon dioxide in exhaled air. Rebreathing of carbon dioxide thus occurs and must be compensated for by increased ventilation. This study aims at determining how much compensation must be given, based on the hypothesis that rebreathing depends on carbon dioxide level in blood and exhaled air.

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Key information

Conditions

Anesthetic Ventilatory Requirements

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital, Cardiothoracic Intensive Care

Lund, SE-221 85, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

elective coronary artery by-pass graft surgery
elective valve replacement surgery
normal left ventricular ejection fraction on preoperative echocardiography

Exclusion criteria

obstructive lung disease
restrictive lung disease

Treatment and study plan

Anesthetic Conserving Device (AnaConDa )

Device

Standard HME was replaced by AnaConDa. AnaConDa has charcoal filter, HME does not.

Primary outcomes

Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas.

Time frame: 1 hour

A conventional heat and moisture exchanger used in a respiratory circuit during anasthesia was exchanged by an AnaConDa. The AnaConDa causes re-breathing of carbon dioxide which clinically is equivalent to an increased airway dead space. The total airway dead space effect of the AnaConDa, i.e. volume of the device plus rebreathing from the charcoal filter was measured using the Single Breath Test for carbon dioxide, as was airway deadspace of the conventional Heat and Moisture Exchanger. Airway dead space differences between devices was calculated by subtraction of volumes thus achieved. Difference= Airway dead space AnaConDa - Airway dead space conventional Heat and Moisture Exchanger.

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Registry information

Official study title

Dead Space Effect of an Anaesthesia Gas Reflector (AnaConDa)

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Apr 20, 2011
Registry last updated: Sep 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.