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NCT Number: NCT07038083

REal-world Data of CARdiometabolic ProtEcTion

This study is a single-center, historical prospective cohort study including patients diagnosed with metabolic cardiovascular disease, including hypertension, diabetes, obesity, dyslipidemia, hyperuricemia. The primary outcome of the study is all-cause death and cardiovascular death, and the secondary outcome is major adverse cardiovascular events. We aim to measure associations of established or suspected cardiometabolic disease (CMD) risk factors and cardiovascular disease outcomes in a real-world representative cohort.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Sun Yat-sen Univerity

Guangzhou, Guangdong, 510000, China

Location status: Recruiting

Location contact

Xiaodong Zhuang

CONTACT

[email protected]

+8613760755035

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 18 years old;
  • Patients with clinical diagnosis of metabolic cardiovascular disease, including hypertension, diabetes, obesity, dyslipidemia, hyperuricemia.
  • Hypertension and normal high blood pressure: Three standardized blood pressure measurements in the clinic on different days, and all the blood pressure values of the three measurements were systolic blood pressure ≥ 120 mmHg and/or diastolic blood pressure ≥ 80 mmHg;
  • Diabetes: ① Typical symptoms of diabetes, and any of the following: ② Random blood glucose ≥ 11.1 mmol/L; ③ Fasting blood glucose (FPG) ≥ 7.0 mmol/L; ④ OGTT 2-hour postprandial blood glucose ≥ 11.1 mmol/L; ⑤ HbA1c ≥ 6.5%;
  • Obesity and overweight: Body mass index (BMI) ≥ 24 kg/m²;
  • Dyslipidemia: At least one of the following lipid indicators is abnormal: ① Total cholesterol (TC) ≥ 6.2 mmol/L; ② Low-density lipoprotein cholesterol (LDL-C) ≥ 4.1 mmol/L; ③ High-density lipoprotein cholesterol (HDL-C) < 1.0 mmol/L; ④ Triglyceride (TG) ≥ 2.3 mmol/L; ⑤ Lipoprotein(a) ≥ 30 mg/dL;
  • Hyperuricemia: The fasting blood uric acid levels on two different days were > 420 μmol/L (7 mg/dL) in men and > 360 μmol/L (6 mg/dL) in women.

Exclusion criteria

  • Patients unable to provide informed consent.

Treatment and study plan

Primary outcomes

  1. all-cause mortality

    Time frame: Through study completion, an average of 5 years

    Death due to any cause after enrollment

  2. Cardiovascular death

    Time frame: Through study completion, an average of 5 years

    Death caused by cardiac causes

Secondary outcomes

  1. Major adverse cardiovascular events

    Time frame: Through study completion, an average of 5 years

    Including heart failure hospitalization, coronary heart disease, stroke, arrhythmia, valvular heart disease, etc.

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaodong Zhuang

CONTACT

[email protected]

+8613760755035

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Registry information

Acronym: RED-CARPET

Important dates

Study start
2014
Primary completion
2044
Study completion
2044
First posted
Jun 26, 2025
Registry last updated
Jun 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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