Skip to main content
OpenTrials
Completed

NCT Number: NCT05694546

Re-engagement at Discharge 2

Early post-discharge mortality is high among Zambians living with HIV admitted to the hospital. This may be due to missed opportunities in post-discharge care, such as inadequate follow-up and treatment. In this study the investigators will develop and pilot a new approach to post-discharge HIV care to improve care coordination and treatment adherence.

Completed

Looking for future studies?

Notify Me

Key information

About this study

Many people living with HIV (PLHIV) have poor outcomes following hospitalization, including high mortality, readmission, and gaps in HIV care engagement. This is likely multi-factorial and not all etiologies may be modifiable. While high mortality may due to incurable cancer, the majority of deaths in PLHIV are thought to be caused by infectious diseases for which treatments exist. However, succumbing to these life-threatening infections after discharge may be due to poor understanding of discharge instructions, lack of post hospital care, and poor understanding of required follow up. Psychosocial support also plays a role in the mental and physical health of these sick patients.

In ReCharge 1, the investigators gathered formative data and identified at least three major factors that undermine HIV clinical outcomes after hospital discharge. First, there are gaps in continuity of care between the discharging facility and outpatient. Second, support from family is often suboptimal due to lack of understanding on the cause of illness, lack of HIV status disclosure, and the cost of care. Third, HIV comorbidities may underpin or complicate the immediate reason for discharge or the post-discharge engagement in care. These data were disseminated to local experts in Zambia including from the Ministry of Health and used to create a new care model for post-discharge HIV care. The care model draws from other successful programs in Zambia. In ReCharge 2 the investigators now propose to pilot the program and assess feasibility, acceptability, and potential for clinical impact.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18+ years
  • HIV-positive
  • Hospitalized for at least 1 night at study site
  • Clinically stable and expected to be discharged according to their clinician
  • Objective evidence of suboptimal HIV outcome, defined as HIV viral load above the lower limit of the assay or T-cell cluster of differentiation 4 count <=200.

Exclusion criteria

  • Unable to provide informed consent
  • No phone
  • Planning to reside outside of Lusaka urban district after discharge

Treatment and study plan

Community Health Worker Post-Discharge Intervention

Behavioral

Clients will be offered a community-based follow-up from a community health worker after hospital discharge.

Primary outcomes

  1. Post-Discharge Visits

    Time frame: Through three months post-discharge

    Proportion of discharged patients who are successfully visited after discharge.

  2. Comprehensive Post-Discharge Visits

    Time frame: Through three months post-discharge

    Number of participants that receive a comprehensive discharge follow-up visit from a community health worker

  3. Post-Discharge Clinic Visits

    Time frame: Through three months post-discharge

    Proportion of initial post-discharge visits to the HIV clinic that are attended by the participant's community health worker

Secondary outcomes

  1. HIV Viral Load Suppression

    Time frame: 6 months post-discharge

    Proportion of clients with suppressed HIV viral load at 6 months post-discharge.

  2. Mortality

    Time frame: 6 months post-discharge

    Proportion of clients alive at 6 months post-discharge.

  3. Retention in HIV Care

    Time frame: 6 months post-discharge

    Retention in HIV care after discharge defined by no gap of >28 days off antiretroviral therapy from discharge date to 6 months post-discharge date

  4. Antiretroviral Therapy Clinic Visit

    Time frame: 1 month post-discharge

    Antiretroviral therapy clinic visit within 1 month of discharge

Sponsors and collaborators

Lead sponsor

University of Maryland, Baltimore

Other

Collaborators

  • University Teaching Hospital, Lusaka, Zambia
  • University of Alabama at Birmingham
  • University of Maryland, College Park

Registry information

Official study title

Re-engagement at Discharge 2: Improving Post-hospital Outcomes for Adults With HIV in Zambia

Acronym: ReCharge2

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jan 23, 2023
Registry last updated
Aug 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.