RCT - Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy

Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times.

The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia.

Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes.

The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including:

* Reduction in the decline of hematocrit levels after surgery. * Reduction of the length of hospital stay

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Key information

Conditions

Myoma;Uterus Adenomyosis Adenomyosis of Uterus Connective Tissue Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Hemorrhage Myofibroma Neoplasms Neoplasms by Histologic Type Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Pathologic Processes Pathological Conditions, Signs and Symptoms Skin and Connective Tissue Diseases Urogenital Diseases Uterine Diseases

Age range

20 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Queen Savang Vadhana Memorial hospital

Si Racha, Changwat Chon Buri, 20110, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female patients who underwent total abdominal hysterectomy

No bleeding tendency.
No history of anticoagulant or thrombolytic drug use
No contraindications to vitamin C supplementation

Exclusion criteria

Inability to communicate in the Thai language.

Underwent total abdominal hysterectomy due to gynecologic malignancy.
Required emergency total abdominal hysterectomy.
History of vitamin C supplementation within 2 weeks prior to surgery.
History of smoking.
Previous abdominal surgery, such as bowel surgery, cesarean section

Treatment and study plan

vitamin C (ascorbic acid)

Dietary Supplement

Received two 1 gm doses of Vitamin C intravenously (IV).

first Dose: At midnight on the day of surgery.

Second Dose: Immediately after the surgical incision.

Primary outcomes

Intraoperative estimate blood loss

Time frame: intraoperative

Sponsors and collaborators

Lead sponsor

Queen Savang Vadhana Memorial Hospital, Thailand

Other

Registry information

Official study title

Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy

Acronym: Vit C in TAH

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2026
First posted: Jan 13, 2026
Registry last updated: Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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