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NCT Number: NCT06712914

Rapid Non-Invasive Brain Stimulation for Hoarding Disorder

This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.

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Key information

Conditions

Hoarding Disorder Anxiety Disorders Behavior Clutter Communication Disorders Hoarding Language Disorders Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Obsessive-Compulsive Disorder Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stanford University Medical Center

Palo Alto, California, 94305, United States

Location status: Recruiting

Location contact

Carolyn Rodriguez, MD, PhD

PRINCIPAL_INVESTIGATOR

Paula Munoz Rodriguez, PhD

CONTACT

[email protected]

650-723-4095

About this study

Hoarding disorder (HD) is characterized by difficulty letting go of possessions, leading to clutter that congests living spaces and impairs daily functioning. The majority of HD patients treated with cognitive behavioral therapy for HD usually experience considerable residual symptoms. New treatments are greatly needed. This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-70 years
  • Primary diagnosis of hoarding disorder
  • Sufficient severity of hoarding symptoms
  • Willing and able to understand and complete consent and study procedures

Exclusion criteria

  • Psychiatric or medical conditions or medications that make participation unsafe
  • Pregnant or nursing females
  • Previous exposure to TMS or ECT
  • History of any implanted device or psychosurgery

Treatment and study plan

MagPro X100 by MagVenture

Device

Participants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100.

Primary outcomes

  1. Change in Compulsive Acquisition Scale (CAS)

    Time frame: Change from baseline to 3 weeks after treatment starts

    The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions.

    The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring.

Other outcomes

  1. Change in Hoarding Symptom Severity as Measured by Saving Inventory-Revised (SI-R)

    Time frame: Change from baseline to 3 weeks after treatment starts

    The Saving Inventory-Revised scale (SI-R) is a 23-item questionnaire with 3 factor-analytically defined sub-scales for difficulty discarding, excessive clutter, and compulsive acquisition.

    The total score (sum of 23 items) ranges from 0 to 92. Total score higher than 41 shows significant difficulty with clutter.

    For the acquisition subscale, items 2 (reverse score), 9, 11, 14, 16, 18 and 21 are summed together. The subscale ranges from 0 to 28 and score greater than 13 indicates difficulty with excessive acquisition.

    For the difficulty discarding subscale, items 4(reverse score), 6, 7, 13, 17, 19, 23 are summed together. The subscale ranges from 0 to 28 and score greater than 13 indicates difficulty with discarding.

    For the clutter subscale, items 1, 3, 5, 8, 10, 12, 15, 20, 22 are summed together. The subscale ranges from 0 to 36 and score greater than 15 indicates difficulty with accumulated clutter.

Study contacts

Contact information is provided by the study sponsor or research team.

Paula Munoz Rodriguez, PhD

CONTACT

[email protected]

650-723-4095

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Acronym: TMS-HOLA

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Dec 2, 2024
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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