Rapid Kidney Function Decline in Older Adults

This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.

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Key information

Conditions

Kidney Function Decline Chronic Disease Chronic Kidney Disease Comorbidity Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glomerular Filtration Rate Healthy Aging Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urine Albumin-creatinine Ratio Urogenital Diseases Urologic Diseases

Age range

70 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Huashan hospital, Fudan university

Shanghai, Shanghai Municipality, 200040, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age greater than 70 years;
GFR data measured at least twice (two years apart) and ACR data measured once (at baseline);
A clear record of the cause of the previous visit; from this, people diagnosed with kidney disease were selected, and kidney disease was defined as various primary nephritis, secondary nephropathy, acute kidney injury (AKI), chronic kidney disease, kidney tumors, or a diagnosis of proteinuria alone.
Signed informed consent form.

Exclusion criteria

People with missing baseline biochemical data;
Outliers in the population indicators, i.e., data deviating from the mean ± three times the standard deviation;
Data with significantly abnormal baseline renal function follow-up (abnormally elevated GFR by more than 10% within 2 years or abnormal ACR value as determined by consultation with a senior nephrologist).

Treatment and study plan

Primary outcomes

A ≥30% decline in glomerular filtration rate (GFR) within 2 years, i.e. a rapid decline in renal function

Time frame: The risk of rapid decline in kidney function in the elderly was assessed during a 2-year follow-up period

Sponsors and collaborators

Lead sponsor

Huashan Hospital

Other

Registry information

Official study title

Identification of Rapid Kidney Function Decline in Older Adults with Different Types of Aging

Important dates

Study start: 2011
Primary completion: 2022
Study completion: 2022
First posted: Jan 9, 2025
Registry last updated: Jan 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed