Rapid Diagnostic Testing and Artemisinin-Based Combination Therapy for Uncomplicated Malaria by Community Health Workers

The purpose of this study is to evaluate the efficiency of a rapid diagnostic test (Paracheck Pf) for the diagnosis of uncomplicated Plasmodium falciparum malaria by community health workers at village level in Tanzania and how the use of rapid diagnostic test may influence prescription of antimalarial drugs.

The hypothesis is that rapid diagnostic tests used by community health workers will reduce the use of antimalarial drugs (Coartem; Novartis) by 30% without affecting the health outcome.

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Key information

Conditions

Uncomplicated Plasmodium Falciparum Malaria

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Villages

Kibaha, Kibaha District, Tanzania

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Fever
Informed consent

Exclusion criteria

Severe clinical manifestations, which require immediate referral
Pregnancy
Previous enrollment in the study within the last 28 days

Treatment and study plan

Rapid diagnostic test for malaria

Device

We used Paracheck Pf® (Orchid Biomedical Systems, India) as rapid diagnostic test in this trial

Primary outcomes

Number of patients with fever prescribed artemether-lumefantrine for the treatment of malaria in respective study groups

Time frame: 28 days

Sponsors and collaborators

Lead sponsor

Karolinska University Hospital

Other

Collaborators

Muhimbili University of Health and Allied Sciences

Registry information

Important dates

Study start: 2006
Study completion: 2006
First posted: Mar 10, 2006
Registry last updated: Nov 1, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed