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NCT Number: NCT06986512

Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection

The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy. By observing parameters such as the size, morphology, scattering intensity, and movement speed of pathogens, combined with the clinical characteristics of patients, a rapid diagnosis of Pseudomonas aeruginosa infection can be made. At the same time, the bronchoalveolar lavage fluid samples of patients infected with Pseudomonas aeruginosa before and after treatment were compared, and the quantity and vitality of Pseudomonas aeruginosa were observed to judge the efficacy of antibiotics.

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Key information

Conditions

Rapid Detection Bacterial Infections Bacterial Infections and Mycoses Gram-Negative Bacterial Infections Infections Pseudomonas Aeruginosa Infection Pseudomonas Infections

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 years and above
  • After admission, Pseudomonas aeruginosa was cultured in bronchoalveolar lavage fluid or lower respiratory tract aspirates

Exclusion criteria

  • Age under 18 years old or over 90 years old
  • Pregnancy, lactation period -

Treatment and study plan

Bronchoscopy

Procedure

We will perform bronchoscopy and collect bronchoalveolar lavage fluid (BALF)

Primary outcomes

  1. The size of pathogens

    Time frame: From enrollment to the end of treatment at 2 weeks

    Measure the size of pathogens

  2. scattering intensity of pathogen

    Time frame: From enrollment to the end of treatment at 2 weeks

    Determine the shape of pathogens through scattering intensity

  3. movement speed of pathogens

    Time frame: From enrollment to the end of treatment at 2 weeks

    Measure the movement speed of pathogens, such as flagellates like Pseudomonas aeruginosa, which have a fast movement speed

Study contacts

Contact information is provided by the study sponsor or research team.

Wenkui Sun, Dr

CONTACT

[email protected]

+86 13914742215

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital with Nanjing Medical University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 23, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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