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NCT Number: NCT06872567

Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain

Multi-center, prospective, randomized trial of GAE using Nexsphere-F against steroid injection

Recruiting

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Key information

Conditions

Knee Osteoarthritis (Knee OA) Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Virginia

Charlottesville, Virginia, 22903, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient has localized knee pain
  • Must be an appropriate candidate for arterial vascular access procedure

Exclusion criteria

  • Known sensitivity or allergy to implant materials
  • Unable or unwilling to comply with study requirements

Treatment and study plan

genicular artery embolization

Device

genicular artery embolization

Corticosteroid injection

Drug

Corticosteroid Injection

Primary outcomes

  1. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

    Time frame: 6 and 12-month post treatment

    Changes in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Scale ranges from 0 to 96 with higher scores equating to greater pain, stiffness and difficulty with activities of daily living.

  2. Serious Adverse Events (SAE)

    Time frame: Treatment, 1,3,6,9 and 12-month post treatment

Secondary outcomes

  1. WOMAC total score

    Time frame: 9 month post treatment

    Changes in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Scale ranges from 0 to 96 with higher scores equating to greater pain, stiffness and difficulty with activities of daily living

Study contacts

Contact information is provided by the study sponsor or research team.

Ziv J Haskal, MD

CONTACT

[email protected]

16463691570

Sponsors and collaborators

Lead sponsor

North American Science Associates Ltd.

Network

Collaborators

  • Next Biomedical Co., Ltd.

Registry information

Official study title

Resorbable Embolization MicroSpheres for OsteoaRthritis Benefit

Acronym: RESORB

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 12, 2025
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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