Randomized a Clinical Trial With Medical Device in Acute Ischemic Stroke

This study seeks to provide high-quality evidence on the potential benefits of the dual stentriever approach, potentially informing future clinical guidelines and improving outcomes in patients with anterior circulation large vessel occlusion strokes.

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Key information

Conditions

Acute Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital de Burgos, Burgos, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18
NIHSS ≥ 6
mRS ≤ 1
Proximal anterior circulation occlusion
ASPECTS > 6
Informed consent

Exclusion criteria

Absence of occlusion
Posterior circulation stroke
Carotid dissection or tandem stenosis requiring treatment
Severe comorbidities or contraindications to imaging contrast

Treatment and study plan

dual sr

Device

Dual Stentriever

Other names: experimental

single sr

Device

Single Stentriever

Other names: control

Primary outcomes

Time takes in achieving complete reperfusion after a single thrombectomy pass.

Time frame: 24 hours or 48 hours after thrombectomy

To evaluate the superiority of the dual stentriever technique in achieving complete reperfusion after a single thrombectomy pass.

Sponsors and collaborators

Lead sponsor

Instituto de Investigación Marqués de Valdecilla

Other

Registry information

Official study title

DUAL VERSUS SINGLE STENTRIEVER FOR RECANALIZATION IN ACUTE ISCHEMIC STROKE: THE RANDOMIZED DOUBLE UP TRIAL

Acronym: DOBLE UP

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Aug 8, 2025
Registry last updated: Aug 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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