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Completed

NCT Number: NCT06980571

Randomised Prospective Study of CUSA Versus Radiofrequency Ablation Technique in Liver Resections

The purpose of this study is to determine whether a particular method of operating on the liver is superior to the "gold" standard commonest technique. CUSA (ultrasonic agitation) will be compared to the newer heat coagulation technique (radiofrequency ablation) and comparisons of blood loss, transfusion requirements, complication rates, hospital stay, effect on liver function, health economics and death rate will be made. The groups will be assessed for comparability in terms of underlying disease, resection type, underlying concurrent illnesses, sex, age, background liver disease. Standardisations of the rest of the operation will be carried out including anaesthetic technique and fluid requirements will be assessed by oesophageal Doppler. 100 patients will be recruited.

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Key information

Conditions

Liver Disease Digestive System Diseases Hemorrhage Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Royal London Hospital

London, E1 1BB, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • any adult patient listed for liver resection giving informed consent

Exclusion criteria

  • children, non-consent and diminished responsibility

Treatment and study plan

Radiofrequency Ablation

Device

FDA approved intervention being compared with gold standard (most common intervention)

Primary outcomes

  1. Blood loss per cm squared of liver parenchyma cut through

    Time frame: operation date until three months from discharge

Secondary outcomes

  1. mortality

    Time frame: inpatient and thirty day mortality

    incidence of post-operative complications measured over a thirty day period

Sponsors and collaborators

Lead sponsor

Barts & The London NHS Trust

Other

Registry information

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
May 20, 2025
Registry last updated
May 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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