Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions

To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with different lung lesions, such as inflammation and lung cancer.

Inclusion criteria

• 18-75 years old, male or female;
• Heart function is normal;
• Normal heart function;
• Estimated survival ≥12 weeks;
• Good follow-up compliance;
• presence of at least one measurable target lesion according to RECIST1.1 criteria;
• Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days before starting the test; Fertile men and women must agree to use effective contraception to prevent pregnancy during the study period and for 3 months after the test;
• Patients recommended by clinicians to undergo PET/CT examination for tumor diagnostic staging;
• The subject patients could fully understand and voluntarily participate in the experiment, and signed the informed consent.

Exclusion criteria

• Serious abnormality of liver, kidney and blood;
• Pregnant patients;
• Pregnant and lactation women;

• unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.