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Enrolling by Invitation

NCT Number: NCT02436941

Radiation Medicine Patient Registry, Loma Linda University Medical Center

For most cancers, long-term follow-up is the best measure of treatment effectiveness. The Department of Radiation Medicine at Loma Linda University Medical Center operates the James M. Slater, M.D., Proton Treatment and Research Center, the world's first hospital-based proton treatment facility. Patients have been treated at the Center since 1990. Radiation treatment has been expanded and refined since the Center's opening, and these changes have been based primarily on outcomes seen and evaluated in long-term follow-up.

The Radiation Medicine Patient Registry (a multi-year database), which began as an IRB-approved study in 2003, including detailed follow-up of study data collected from 1990 and onward, is designed to track all medical information from patients treated with proton therapy and/or conventional X-ray therapy at Loma Linda University Medical Center. Information gathered from patients treated years or even decades ago helps to determine the most effective use of proton and conventional radiation in caring for patients with cancers and other diseases.

Enrolling by Invitation

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Key information

Conditions

Cancer Neoplasms

Age range

Up to 99 year

Sex eligibility

All sexes

Study type

Observational

About this study

The patient registry will be posted to accomplish three objectives:

  • Perform retrospective research studies on diseases treated with proton therapy and conventional photon radiation.
  • Maintain regular and life-long contact with patients in order to obtain current identification, contact information, and self/parent-reported health status. This information is used to generate better understanding of treatment strategies and, in turn, increase benefits to patients.
  • Enable physicians to review of medical record information and so to identify subjects who may be eligible to participate in future research studies. This requires obtaining permission from registered participants that they may be contacted and asked if they are interested in participating in studies for which they may be eligible, as determined by their medical information contained in the registry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of benign or malignant tumors or other conditions deemed treatable by proton or conventional photon radiotherapy
  • Willingness to sign an Informed Consent Document

Exclusion criteria

  • There are no specific exclusion criteria, but patients who are unwilling to sign the ICD will not be included

Treatment and study plan

Proton or Photon

Radiation

Primary outcomes

  1. Disease-free survival

    Time frame: One year

    Participants will be followed per protocol pre- during- and following treatment per protocol schedule

Secondary outcomes

  1. Local recurrence

    Time frame: One year

    Participants will be followed per protocol pre- during- and following treatment per protocol schedule

Other outcomes

  1. Number of patients with adverse events

    Time frame: One year

    Participants will be followed per protocol pre- during- and following treatment per protocol schedule

  2. Overall survival & Long-term follow-up

    Time frame: One year

    Maintaining regular, lifetime contact with patients enables physicians to obtain current identification, contact information, and self/parent-reported health status that can, in turn, generate better understanding of treatment strategies and subsequent benefits to patients

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Registry information

Official study title

Loma Linda University Medical Center Department of Radiation Medicine Patient Registry

Important dates

Study start
2003
Primary completion
2040
Study completion
2050
First posted
May 7, 2015
Registry last updated
May 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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