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OpenTrials
Completed

NCT Number: NCT00178295

Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

Treatment for brain cancer may include radiation therapy. Radiation therapy is the treatment of tumors with X-rays. This study is related to understanding the side effects of radiation treatment for brain tumors.

This study is being conducted by the University of Rochester Cancer Center to compare the extent of side effects of brain cancer treatment with changes in levels of blood proteins called cytokines.

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Key information

Conditions

Brain Neoplasm Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Rochester, Dept. Radiation Oncology

Rochester, New York, 14642, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any patient who will be treated to the brain or spinal axis for a CNS tum Patients so treated will be stratified according to whether or not the hypo is included in the treatment fields.
  • Patients receiving external beam radiation to the brain may also be rece chemotherapy or interferon-beta. (Add. #1, 11-9-95)
  • Patients receiving high dose rate (stereotactic radiosurgery) are eligible.
  • Patients must sign a study specific informed consent meeting all federal a guidelines.
  • Patients of any age, including children, are eligible (Add. #3, 11/25/97).

Exclusion criteria

  • Patients who have a malignancy involving the hypothalamic-pituitary ax
  • Patients who are not treated with irradiation to the brain or spinal axis.

Treatment and study plan

radiation therapy

Radiation

standard of care for the cancer being treated

Primary outcomes

  1. Change from baseline in Cytokine blood levels

    Time frame: 12 weeks from start of radiation

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Registry information

Important dates

Study start
1999
Primary completion
2013
First posted
Sep 15, 2005
Registry last updated
Aug 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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