Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

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Key information

Conditions

Preeclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

University of MS Medical Center

Jackson, Mississippi, 39216, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

African-american or Caucasian
Pregnant
Between ages of 18 - 40 years of age

Exclusion criteria

Presence of a disease or condition which is not preeclampsia
Drug or alcohol abuse during pregnancy
Obesity

Treatment and study plan

Primary outcomes

Nitric oxide and Endothelin-1 levels

Time frame: 48 hours after tissue collection

Secondary outcomes

Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome

Time frame: within 6 months from tissue collection

Sponsors and collaborators

Lead sponsor

University of Mississippi Medical Center

Other

Collaborators

Mississippi Institute for Improvement of Geographic Minority Health
Office of Minority Health

Registry information

Official study title

Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2009
First posted: Apr 7, 2008
Registry last updated: Apr 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed