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Recruiting

NCT Number: NCT05958667

Quitxt Mobile Text Messaging Cessation Research Study

The health benefits of smoking cessation by age 30 are much greater than cessation later in life, including gaining 10 years of life, compared with those who continue to smoke. The goal of the proposed study is to evaluate the effectiveness of the bilingual and culturally tailored Quitxt mobile cessation intervention. Quitxt provides interactive messages through texts or chat with visual and video content employing theory- and evidence-based techniques to prompt and sustain cessation. The study will recruit 1,200 Latino young adult smokers aged 18-29 who enroll and agree to make quit attempts, with half randomly assigned (like flipping a coin) to receive Quitxt and half to abbreviated text messages with smoking cessation-related content and referral to the Texas Department of State Health Services cessation program Yes Quit (which has diverse formats, but not explicitly tailored for young Latino adults in South Texas). Participants respond to baseline and follow-up assessments at one, three and six months after their enrollment, and those who report cessation will be asked to provide saliva samples to confirm they quit smoking. The sample size will be sufficient to detect expected higher cessation rates in those who are enrolled in Quitxt than those who are enrolled in Texas DSHS Yes Quit. The investigators will publish results in scientific journals, report them at scientific and community meetings, share them on social media, and publicize them widely. This study has the potential to advance public health by evaluating the effectiveness of a scalable, easily disseminated and adaptable intervention to help young adults, especially Latinos, quit smoking and reduce smoking-related cancer and chronic disease morbidity and mortality and their associated healthcare costs.

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Key information

Age range

18 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

Location status: Recruiting

Location contact

Patricia Chalela, DrPH

CONTACT

[email protected]

210-562-6513

About this study

Despite major advances in tobacco control and treatment, tobacco use remains the single largest preventable cause of morbidity and mortality in the US. Smoking prevalence is highest among Texas young adults (ages 18-29) and even higher among those with less than a high-school education and those living in rural areas and at or below the poverty level, such as Latinos. About 19.2% of Latinos ages 18-29 in the study areas are current smokers placing them at higher risk of cancer and other tobacco-related morbidity and mortality. Young adults are heavy users of smartphones, text messaging, social media chats and other mobile social media, providing a remarkable opportunity for innovation in the delivery of health promotion services to reduce health disparities in this large and rapidly growing racial/ethnic population. New social media have an extraordinary theoretical potential for assisting smoking cessation by providing peer modeling and eliciting social reinforcement for behavior change. The goal of this project is to experimentally evaluate Quitxt, a culturally appropriate mobile smoking cessation program. Quitxt - launched by an interdisciplinary research team using proven social cognitive, motivational interviewing, and brief intervention methods for promoting behavior change - blends bilingual text and social media messaging for smoking cessation tailored to the language and culture of young adult smokers in the vulnerable region of South Texas. Quitxt has not been tested in a research study, as its creation as an evidence-based cancer prevention service for young adult smokers was supported by the Cancer Prevention and Research Institute of Texas (CPRIT). To study the effects of Quitxt, the study team will recruit 1,200 young adult (ages 18-29) Latino Spanish- and English-speaking smokers over the 5-year study interval in South Texas. A two-group parallel randomized controlled trial will be conducted to compare rates of smoking cessation: 1) the intervention group will receive the innovative Quitxt text messaging or the chat mobile service; and 2) the usual care group will receive abbreviated text messaging with smoking cessation-related content and referral to the Texas Department of State Health Services (TDSHS) cessation program Yes Quit (www.yesquit.org). The investigators will measure effects online at time of enrollment and again at one, three and six months later. The investigators will validate reports of smoking cessation via biological tests, for those who report smoking cessation at one, three and six-month follow-ups. The investigators hypothesize that the group receiving the Quitxt intervention will achieve significantly higher smoking cessation rates than the group receiving usual care. This study will expand research on the health of young adult Latinos by testing an innovative, mobile, culturally, and linguistically appropriate intervention to reduce smoking among young adult Latino smokers by enhancing their skills development, competence, and self-efficacy to initiate and maintain cessation. Moreover, this study will advance public health by testing the effectiveness of a scalable, evidence-based, easily disseminated, and adaptable intervention with potentially broad national reach to help young adults stop smoking and reduce smoking-related cancer and chronic disease morbidity and mortality and their associated healthcare costs.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Latinos
  • aged 18-29 years;
  • smoking at least one cigarette/day ≥3 days/week;
  • interested in quitting;
  • willing to provide follow-up data;
  • are not simultaneously participating in a cessation program;
  • own a cell phone or smartphone;
  • are able to send and receive text messages and access the Internet;
  • reside in the study area; and
  • able to provide informed consent to participate in the study.

Exclusion criteria

  • are not interested in quitting;
  • are unable to provide consent due to a mental, emotional, or physical handicap that keep them from understanding the consent information;
  • do not own a cell phone with text and Internet capabilities;
  • are unable to respond to text messages and questions or unable to view the study mobile webpages/YouTube videos (i.e., if they are blind, deaf); or
  • are planning to move from the study area within the study time span.

Treatment and study plan

Quitxt text messaging or Chat

Behavioral

Mobile intervention using proven social cognitive, motivational interviewing, and brief intervention methods for promoting behavior change - blends bilingual text and social media messaging for smoking cessation tailored to the language and culture of young adult smokers in our vulnerable region of South Texas.

Other names: Culturally appropriate mobile smoking cessation proram

Usual Care

Other

Abbreviated text messaging with smoking cessation-related content and referral to the Texas Department of State Health Services (TDSHS) cessation program Yes Quit.

Other names: Abbreviated text messaging with smoking cessation-related content

Primary outcomes

  1. Smoking cessation

    Time frame: 6 months

    Measure of smoking cessation (7-day point prevalence abstinence)self-reported and biochemically verified.

Secondary outcomes

  1. Smoking cessation assessment

    Time frame: 1 month and 3 months

    Measure of smoking cessation (7-day point prevalence abstinence)self-reported and biochemically verified.

Study contacts

Contact information is provided by the study sponsor or research team.

Patricia Chalela, DrPH

CONTACT

[email protected]

(210) 562-6513

Vivian Cortez, MS

CONTACT

[email protected]

(210) 562-6528

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center at San Antonio

Other

Collaborators

  • Cancer Prevention Research Institute of Texas
  • The University of Texas at San Antonio

Registry information

Official study title

Randomized Controlled Trial to Assess Innovative Smoking Cessation Services for Young Adults in Texas

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jul 24, 2023
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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