Quantum Molecular Resonance (QMR) Rehabiltative Treatment of Knee Osteoarthritis

For the in vivo study, a double-blind randomized controlled clinical trial will be conducted. Both male and female subjects, aged between 40 and 80 years, with knee pain both in the acute and chronic phase of gonarthosis, diagnosed on standard radiography, will be enrolled. Patients will be randomized into 2 groups treated with an intensive or extensive protocol, and a third untreated control group. They will be evaluated at T0 (before treatment), at T1 (end of QMR treatment), and at T2 (one month after the end of treatment (follow-up). All patients will be assessed for pain and functionality, furthermore synovial fluid and blood sampling will be performed, for the quantitative assessment of the inflammatory state considering the levels of the main pro-inflammatory cytokines and the pro/anti-inflammatory macrophage phenotype.

Inclusion criteria

Both male and female subjects, aged between 40 and 80 years, with knee pain both in acute and chronic phase due to gonarthosis diagnosed on standard radiography will be enrolled.

• Diagnosis of gonarthrosis with VAS >3
• Presence of acute or chronic pain (the sample will be stratified in one phase next)
• Radiographic picture of gonarthrosis and staging score according to Kellegren-Lawrence classification (I-II-III)

Exclusion criteria

favism, hemolytic anemia

• severe hyperthyroidism - Graves' disease;
• drug treatment with Tapazole;
• thrombocytopenia less than 50,000 and serious coagulation disorders;
• severe cardiovascular instability;
• coagulation defects;
• alcohol abuse;
• hemochromatosis;
• patients being treated with food-nutraceutical supplements;
• pregnancy and bed rest;
• psychiatric pathologies;
• less than three months from previous knee infiltrations
• septic arthritis and/or febrile states
• anamnestic contraindications to the instrumental physical therapy in use (tumor pathologies past)

Furthermore, the following subjects will be excluded from the study:

• with rheumatic and autoimmune diseases
• patients with recent history of trauma and/or knee (ligament) sprain injuries