Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects

T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution.

In this study we aim to characterise the normal appearance of T1rho in the brain parenchyma in healthy participants. T1rho values will be measured in normal brain structures.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Magnetic Resonance Imaging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CUHK

Hong Kong

Location status: Recruiting

Location contact

Tiffany So

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male and female volunteers greater than or equal to 18 years of age

Exclusion criteria

Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy.
Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis
Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Treatment and study plan

T1rho imaging

Diagnostic Test

Magnetic Resonance Imaging using T1rho

Primary outcomes

T1rho value in normal grey and white matter in healthy volunteers

Time frame: Up to 2 months

T1rho value (measured on T1rho weighted MRI) in normal grey and white matter in healthy volunteers

Study contacts

Contact information is provided by the study sponsor or research team.

Tiffany So

CONTACT

[email protected]

+85235051035

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Important dates

Study start: 2021
Primary completion: 2028
Study completion: 2028
First posted: Aug 6, 2021
Registry last updated: Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting