Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)

Inclusion criteria

Patients

• Patients who have provided written informed consent
• Patients with national health insurance cover
• Age: 50 to 90 years

Patients with Horton' s disease :

• at the diagnosis, before any treatment
• or in remission
• or in relapse

Patients with an infectious disease :

• Bacteriologically or radiologically confirmed
• Presenting an inflammatory syndrome defined by :
• CRP ≥ 10 mg / L
• and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1

Patients with neoplasia ( solid tumour or hemopathy ) :

• At the diagnosis, before treatment by chemotherapy
• Presenting an inflammatory syndrome defined by:
• CRP ≥ 10 mg / L
• and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1

Controls :

These are healthy volunteers recruited among blood donators at Dijon CHU, voluntary hospital personnel ( nurses, doctors and secretaries ), patients at the EPHAD ( Champmaillot centre for geriatric patients ) and patients without infectious, inflammatory, or auto-immune disease ( CRP < 5mg / L ) or cancer recruited from the investigating departments of Dijon CHU. They will be matched for age and sex.

• Age: 18 - 90 years
• Patients with national health insurance cover
• who have provided written informed consent
• Absence of an inflammatory syndrome ( CRP < 5 mg / L )

Exclusion criteria

• Any patient who does not meet the inclusion criteria