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OpenTrials
Completed

NCT Number: NCT04952025

Quantitative Analysis of Precise Brain Volume in Amyotrophic Lateral Sclerosis

Using the original MRI images of 16 ALS patients and 16 normal controls matched by gender, age and education level in the previous study, the differences of brain volume in different parts of ALS patients and normal controls, and the correlation between brain structure and clinical characteristics were compared by precise brain volume quantitative analysis technology.

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Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Study type

Observational

Primary location

Peking University Third Hospital

Beijing, Beijing Municipality, 100000, China

About this study

This study was a retrospective study. The subjects were 16 ALS patients and 16 normal controls. Previous studies have collected patients' age, gender and education level; The onset site, onset time, bulbar involvement, diagnostic grade, ALSFRS-R score, application of ventilator, application of lirutai, gastrostomy; Age, gender and education level were collected in the control group. Accurate quantitative analysis of brain volume was performed on the original brain MRI images of the two groups.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed ALS patients
  • healthy volunteers

Exclusion criteria

  • none

Treatment and study plan

Diagnostic criteria

Diagnostic Test

Diagnostic criteria of ALS

Primary outcomes

  1. Accurate quantitative analysis of brain volume

    Time frame: 1 day

    Accurate quantitative analysis of brain volume using magnetic resonance brain imaging

Secondary outcomes

  1. general situation

    Time frame: 1 day

    Age, gender and education level were collected; Onset site, onset time, involvement of bulbar, diagnostic grade, ALSFRS-R score, application of ventilator, application of lirutai, gastrostomy

Sponsors and collaborators

Lead sponsor

Peking University Third Hospital

Other

Collaborators

  • Chinese University of Hong Kong

Registry information

Official study title

Brain Imaging Study of Amyotrophic Lateral Sclerosis Based on Accurate Brain Volume Quantitative Analysis

Important dates

Study start
2015
Primary completion
2021
Study completion
2021
First posted
Jul 7, 2021
Registry last updated
Jul 7, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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