Quantifying Nitrous Oxide Effect on Depth of Anaesthesia Using Theoretically Based Time Series Modelling

Our hypothesis is that a new method of depth of anaesthesia monitoring, using theoretically based time series modelling will result in improved ability to determine nitrous oxide anaesthetic effect

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Key information

Conditions

Depth of Anaesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Swinburne University, Hawthorn, Victoria, Australia

About this study

We randomised patients to 0% 33% or 66% nitrous oxide during sevoflurane induction and measured anesthetic endpoints.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged 18 years or older
Presenting for surgery under general anaesthesia

Exclusion criteria

Poor English language comprehension
Risk of reflux
Epilepsy or other EEG abnormality

Treatment and study plan

Nitrous Oxide

Drug

nitrous oxide by inhalation during induction

Other names: No other names were used

Primary outcomes

EEG index value during three concentrations of nitrous oxide

Time frame: During induction of anaesthesia

Sponsors and collaborators

Lead sponsor

Melbourne Health

Other

Collaborators

Australian and New Zealand College of Anaesthetists

Registry information

Important dates

Study start: 2004
Primary completion: 2005
Study completion: 2005
First posted: Sep 27, 2005
Registry last updated: Feb 5, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed