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NCT Number: NCT07325175

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are:

How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)?

Participants will:

* Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

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Key information

Conditions

Dystonia Deep Brain Stimulation Dyskinesias Motor Development Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Pediatric Signs and Symptoms

Age range

6 year–21 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

Location status: Recruiting

Location contact

Karlee Migneault

CONTACT

[email protected]

513-636-4200

Travis Larsh, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For dystonia subjects:
  • Dx of dystonia (with and without DBS)
  • willingness and ability to complete study protocols.
  • For Typically Developing Controls:
  • normal developmental milestones
  • absence of any neuropsychiatric disorder
  • no significant medical condition.

Exclusion criteria

  • history of epilepsy
  • presence of implanted medical devices (except DBS in dystonia subjects)
  • lack of cognitive or physical ability to complete study protocol.

Treatment and study plan

DBS

Device

Subjects with DBS will complete protocol with and without active stimulation

Primary outcomes

  1. Longitudinal change in Motor Network Aperiodic Activity

    Time frame: -Baseline -Through study completion, an average of 2 years

Secondary outcomes

  1. Longitudinal change in Motor Network Periodic Activity

    Time frame: -Baseline -Through study completion, an average of 2 years

  2. Longitudinal change in Motor Network EEG connectivity

    Time frame: -Baseline -Through study completion, an average of 2 years

Sponsors and collaborators

Lead sponsor

Children's Hospital Medical Center, Cincinnati

Other

Registry information

Important dates

Study start
2024
Primary completion
2029
Study completion
2029
First posted
Jan 8, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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