Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07577752

Quantifying Blood Flow in the Aorta

This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

TechMed centre, University of Twente

Enschede, Overijssel, 7522 NH, Netherlands

Location status: Recruiting

Location contact

Cindy D. Lammertink, drs.

CONTACT

[email protected]

+31534895350

Hadi Mirgolbabaee, dr.

SUB_INVESTIGATOR

Marleen E. Krommendijk, ir.

SUB_INVESTIGATOR

About this study

The goal of this observational study is to obtain PC 4D flow MRI scans in seventy healthy volunteers (without any known history of cardiovascular disease) to quantify local blood flow in the thoraco-abdominal aorta and its primary side branches and extract boundary conditions for future in-vitro and in-silico studies. Furthermore, the 3D geometry of the vessels within investigated FOVs, starting from ascending aorta to internal/external iliac arteries, will be obtained by performing a separate MRI sequence.

Participants will be asked to undergo MRI scans and are asked to fill out a questionnaire regarding their age, weight, height, and gender. By relating this data to the blood flow patterns observed in the aorta, conclusions can be drawn on the differences in blood flow with gender and how aortic blood flow changes with age.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy (in particular without any cardiovascular disease or history thereof) men or women
  • 18 years of age or above;
  • BMI ≤ 30;
  • Willingness to undergo MRI scans;
  • Able to provide signed informed consent (IC)

Exclusion criteria

  • Irregular heartbeat.;
  • Any history of cardiovascular disease or current cardiovascular disease;
  • The standard MRI exclusion criteria (such as pacemakers, cerebral vascular clips, pregnancy, claustrophobia)

Treatment and study plan

4D-flow Magnetic Resonance Imaging

Other

Subjects will undergo MRI scans of the thorax and abdomen from which we will derive aortic blood flow velocity fields. This intervention will be performed in the same manner on all groups.

Other names: Magnetic Resonance Imaging, Phase contrast MRI, PC-MRI

questionnaires

Other

Subjects fill in a questionnaire regarding their weight, height, age and gender. They also fill in a safety check form to test if MRI can be applied safely.

Primary outcomes

  1. Aortic blood flow velocity fields

    Time frame: Day 1

    Velocity fields will be acquired, consisting of vectors that describe the velocity magnitude (cm/s) and direction (dimensionless) of blood flow in the aorta. For visualisation purposes, arrows will be used to overlay the shape of the volunteers aorta. Colours of the arrrows indicate the velocity magnitude and direction of the arrows inicate the direction of flow. Velocity fields are generated for the the full aorta, from the ascending aorta to internal/external iliac arteries, including branched arteries such as subclavian arteries, common carotid artery, and visceral branch vessels.

Secondary outcomes

  1. Age of volunteer

    Time frame: Day 1

    Age of volunteer (in years) for division into groups based on gender and age, gathered using a questionnaire.

  2. Gender of volunteer

    Time frame: Day 1

    Gender of volunteer (male/female/other) for division into groups based on gender and age, gathered using a questionnaire.

  3. Height of volunteer

    Time frame: Day 1

    Height (in m) for BMI (in kg/m^2) calculation, gathered using a questionnaire.

  4. Weight of volunteer

    Time frame: Day 1

    Weight (in kg) for BMI (in kg/m^2) calculation, gathered using a questionnaire.

  5. Aortic blood flow waveforms

    Time frame: Day 1

    Waveforms will be acquired that show how aortic blood flow in a certain region of interest progresses over the cardiac cycle, presented as plots of velocity magnitude (cm/s) over time (s). Regions of interest are selected in the ascending aorta, descending aorta, carotid arteries, subclavian arteries, renal arteries, suprarenal aorta, abdominal aorta, common iliac arteries, internal iliac arteries, and external iliac arteries.

  6. Wall shear stress

    Time frame: Day 1

    Wall shear stress (Pa) is a hemodynamic parameter expressing the force acting on a certain area of the vessel wall by the flow of blood. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

  7. Oscillatory Shear Index

    Time frame: Day 1

    Oscillatory Shear Index (dimensionless) is a hemodynamic parameter that defines how much the wall shear stress field changes directions over time, which can tell something about whether the forces on the wall (and the flow of blood) are more uniform or more complex. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

  8. Kinetic Energy

    Time frame: Day 1

    Kinetic Energy (J) in the field of fluid mechanics describes the energy related to the flow of blood in a certain region of interest with a certain mass or volume. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

  9. Turbulent Kinetic Energy

    Time frame: Day 1

    Turbulent Kinetic Energy (J/kg) is a hemodynamic parameter describing the energy related to the fluctuations in blood flow velocity. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

  10. Helicity

    Time frame: Day 1

    Helicity (m^4/s^2) is a hemodynamic parameter that describes how much the blood flow follows a corkscrew-like pattern. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

  11. Vorticity

    Time frame: Day 1

    Vorticity (s^-1) is a hemodynamic parameter that reflects the rotational nature of the blood flow. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle.

Study contacts

Contact information is provided by the study sponsor or research team.

Marleen E. Krommendijk, ir.

CONTACT

[email protected]

+31534894988

Sponsors and collaborators

Lead sponsor

University of Twente

Other

Registry information

Official study title

Quantifying Blood Flow in the Aorta Using Phase-Contrast 4D Flow MRI - Phase 2

Acronym: AF-4DMRI-P2

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 11, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.