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OpenTrials
Completed

NCT Number: NCT04988490

Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes

To determine how daily cannabis use affects surgical outcomes.

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Key information

Conditions

Post-surgical Pain Cancer Cannabis Use Chemically-Induced Disorders Marijuana Abuse Mental Disorders Neoplasms Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Post-Surgical Complication Postoperative Complications Signs and Symptoms Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Colorado Hospital

Denver, Colorado, 80045, United States

About this study

To determine if patients who are daily cannabis users that are undergoing inpatient abdominal surgery for the treatment of cancer are different from non-cannabis users regarding phytocannabinoid and endocannabinoid levels, pain scores, pain medication requirements, and surgical complications.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients > 18 years old
  • Undergoing abdominal surgery for the treatment of cancer
  • Report no cannabis use in the last year or chronic cannabis use (defined as at least weekly use for 3 months or more)

Exclusion criteria

  • patients with chronic pain, chronic pain syndrome on opioids
  • female patients who are pregnant or lactating
  • patients who report use of illicit substances

Treatment and study plan

Primary outcomes

  1. Postoperative opioid consumption

    Time frame: 30 days

    Postoperative opioid consumption among daily cannabis using and non-cannabis using patients undergoing abdominal surgery for cancer

  2. Correlation of postoperative opioid consumption

    Time frame: 30 days

    Correlation between serum phytocannabinoid and endocannabinoid levels, pain scores, and postoperative opioid consumption

  3. Correlation of postoperative complications

    Time frame: 30 days

    Correlation between 30-day post-operative complications, preoperative, and postoperative phytocannabinoid and endocannabinoid levels

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Collaborators

  • Institute of Cannabis Research
  • National Cancer Institute (NCI)

Registry information

Official study title

Quantification of Endo- and Phytocannabinoids With Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Aug 3, 2021
Registry last updated
Mar 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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