Quality of Pediatric Resuscitation in a Multicenter Collaborative

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.

The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.

Recruiting

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Key information

Conditions

Cardiac Arrest Cardiopulmonary Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

0 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Children's Hospital at Westmead, Westmead, New South Wales, Australia

About this study

Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.

Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient received chest compressions for at least 1 minute
Patient between gestational age ≥37 weeks and 18 years of age

Exclusion criteria

Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

Treatment and study plan

Primary outcomes

Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR

Time frame: 10 Years

Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.

Study contacts

Contact information is provided by the study sponsor or research team.

Kathryn Graham

CONTACT

[email protected]

215-590-1859

Vinay Nadkarni, MD, MS

CONTACT

[email protected]

215-590-7430

Sponsors and collaborators

Lead sponsor

Children's Hospital of Philadelphia

Other

Collaborators

Zoll Medical Corporation

Registry information

Official study title

Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study

Acronym: pediRES-Q

Important dates

Study start: 2016
Primary completion: 2030
Study completion: 2030
First posted: Mar 15, 2016
Registry last updated: Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed