CHU de Nice
Nice, Alpes Maritimes, 06000, France
Not Yet Recruiting
NCT Number: NCT07340749
Quality of Life in Hereditary and Inflammatory Peripheral Neuropathies
Neuromuscular diseases affect the nerves and muscles and can cause weakness, pain, fatigue, and difficulties in daily life. These problems may reduce independence, social participation, and overall quality of life.This observational study aims to evaluate the impact of peripheral neuropathies on quality of life. It focuses on two types of peripheral neuropathies: hereditary neuropathies, caused by genetic factors, and inflammatory neuropathies, caused by immune-related nerve damage. Adult patients with these conditions will be assessed at a single time point, without any change to their usual medical care. Participants will complete questionnaires about daily functioning, well-being, and quality of life. Some questions will also explore the use of assistive devices and supportive tools in everyday life.The study hypothesizes that peripheral neuropathies significantly affect quality of life and that this impact differs between hereditary and inflammatory forms. The results aim to improve understanding of patients' needs and support better, more personalized care."
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Clinical and paraclinical diagnosis compatible with hereditary or inflammatory peripheral neuropathy, confirmed by the investigating physicians (genetic results for HPN if available; clinical/electrophysiological criteria for IPN).
- Written informed consent.
- Ability to complete the questionnaires (or with the assistance of a caregiver if necessary, specifying the mode of assistance).
Exclusion criteria
- Legal incapacity (under guardianship or conservatorship).
- Moderate to severe cognitive impairment (e.g., MMSE < 27) preventing valid comprehension and completion of the questionnaires.
- Active cancer undergoing chemotherapy or radiotherapy (treatment likely to significantly alter quality of life in a non-specific way).
- Other acute serious medical conditions that could interfere with assessment, at the investigator's discretion.
Treatment and study plan
WHODAS 2.0 questionnaire
OtherWHODAS 2.0: Assesses daily functioning and disability across six domains: understanding, mobility, self-care, interpersonal relationships, domestic activities, and social participation.
WHOQOL-BREF: Measures overall quality of life in four domains: physical, psychological, social relationships, and environment.
MPT Questionnaire (SOTU and ATD PA): Evaluates participants' attitudes, perceptions, and professional practices in a specific organizational or educational context.
Other names: WHOQOL BREF questionnaire, MPT Questionnaire (SOTU e ATD PA)
Primary outcomes
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Quality of life (WHOQOL-BREF score)
Time frame: At the inclusion
Quality of life (WHOQOL-BREF score) at baseline (M0) in patients with hereditary peripheral neuropathy (HPN) and inflammatory peripheral neuropathy (IPN)
Secondary outcomes
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Comparison of perceived quality of life
Time frame: At the inclusion
Comparison of perceived quality of life between HPN and IPN groups using WHOQOL-BREF scores
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Association between functioning and quality of life
Time frame: At the inclusion
correlation between WHODAS 2.0 scores and WHOQOL-BREF scores.
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Factors associated with impaired functioning and quality of life
Time frame: At the inclusion
identification of clinical or demographic variables linked to lower WHODAS 2.0 or WHOQOL-BREF scores.
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Role of assistive technologies (MPT)
Time frame: At the inclusion
Evaluation of the impact or use of assistive technologies on functioning and quality of life.
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Profile of limitations
Time frame: At the inclusion
Assessment using WHODAS 2.0 scores to describe functional limitations
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Activity restrictions
Time frame: At the inclusion
Assessment using WHODAS 2.0 scores
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Environmental factors
Time frame: At the inclusion
Assessment using WHODAS 2.0 scores
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Centre Hospitalier Universitaire de Nice
Other
Registry information
Official study title
Cross-sectional Observational Study on the Impact of Neuromuscular Diseases on Quality of Life: Focus on Peripheral Neuropathies (Hereditary vs Inflammatory)
Important dates
- Study start
- 2026
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jan 14, 2026
- Registry last updated
- Jan 14, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.