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Completed

NCT Number: NCT07416838

Quality of Life and Cognitive Functioning in Patients With Glial Tumors

The aim of this study is to introduce appropriate assessment instruments and to define patients with gliomas according to cognitive functioning and quality of life. The study will evaluate cognitive functioning as a prognostic factor for survival in patients with glial tumors and will support optimization of treatment strategies to improve patients' quality of life.

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Key information

Conditions

Glial Tumors Glioma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Oncology Ljubljana

Ljubljana, 1000, Slovenia

About this study

This prospective cohort study will assess cognitive functioning and quality of life in patients with glial tumors. The objective is to determine the prognostic value of cognitive functioning on survival, establish appropriate assessment instruments, and contribute to treatment adaptation with the goal of improving quality of life in these patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult participants (≥18 years)
  • Patients with histologically confirmed glial tumour
  • Ability to understand the study procedures and provide written informed consent
  • Ability to complete quality of life questionnaires and cognitive testing

Exclusion criteria

  • Age <18 years
  • Inability to provide informed consent
  • Severe cognitive impairment or clinical condition preventing completion of questionnaires and cognitive testing
  • Insufficient language proficiency to complete the questionnaires and neuropsychological testing

Treatment and study plan

Cognitive Functioning and Quality of Life Assessment

Other

Assessment of cognitive functioning and quality of life in patients with glial tumors to evaluate their prognostic value and impact on survival outcomes.

Primary outcomes

  1. Change in Quality of Life Score (EORTC QLQ-C30 and QLQ-BN20)

    Time frame: Baseline (before treatment); 6 weeks; 3 months; 6 months; 12 months

    Quality of life will be assessed using the European Organisation for Research and Treatment of Cancer questionnaires EORTC QLQ-C30 and the brain cancer module EORTC QLQ-BN20. Scores range from 0 to 100 points. The outcome will be reported as mean change in questionnaire score (points) from baseline to each follow-up assessment.

Secondary outcomes

  1. Change in Cognitive Function Test Performance (Neuropsychological Test Battery)

    Time frame: Baseline (before treatment); 6 weeks; 3 months; 6 months; 12 months

    Cognitive functioning will be assessed using a neuropsychological test battery evaluating multiple cognitive domains (e.g., language, memory, executive functioning). The outcome will be reported as mean change in test scores from baseline to each follow-up assessment.

Sponsors and collaborators

Lead sponsor

Institute of Oncology Ljubljana

Other

Registry information

Official study title

Quality of Life and Cognitive Functioning as Prognostic Factor in Glial Tumours

Important dates

Study start
2018
Primary completion
2024
Study completion
2024
First posted
Feb 18, 2026
Registry last updated
Feb 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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